TPDB

3D PDB MODEL

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TPDB ID TPDB25932

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

Peptipedia Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 47-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.

Sequence

TLVDPERCSKMYGQCRTRCYKIEKQIDICYSPSKICCIQRAFEEDLS

FASTA

>TPDB25932|Antibacterial;Antifungal|length=47
TLVDPERCSKMYGQCRTRCYKIEKQIDICYSPSKICCIQRAFEEDLS

Formula C236H382N66O74S7

Absent Amino Acids NHW

Common Amino Acids C

Mass 5552.45

PI 7.62

Basic Residues 8

Acidic Residues 7

Hydrophobic Residues 14

Net Charge +1

Boman Index 14.03

Hydrophobicity -0.530

Aliphatic Index 66.38

Half Life

Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 4845

Absorbance 280nm 87.26

Polar Residues 18

number

1

A

4

R

0

N

3

D

6

C

4

E

3

Q

1

G

0

H

5

I

2

L

4

K

1

M

1

F

2

P

4

S

2

T

0

W

3

Y

1

V

Amino Acid Distribution

A: 1 R: 4 N: 0 D: 3 C: 6 E: 4 Q: 3 G: 1 H: 0 I: 5 L: 2 K: 4 M: 1 F: 1 P: 2 S: 4 T: 2 W: 0 Y: 3 V: 1

Length

47

Formula

C236H382N66O74S7

Mass

5552.45

PI

7.62

Net Charge

+1

Boman Index

14.03

Hydrophobicity

-0.530

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >512 µg/mL

Target

Target Organism S.aureus CICC10384

Source & Reference

Database Source NA

Other

Evidence Text

K88+ (MIC 11.5-23 uM), S.typhimurium ATCC14028 (MIC >512 ug/ml or 92 uM), Streptococcus, S.aureus CICC10384 (MIC >512 ug/ml), and B.subtilis (MIC>512 ug/ml), and fungus P.pastoris X33 (512 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >512 µg/mL

Target

Target Organism B.subtilis

Source & Reference

Database Source NA

Other

Evidence Text

C14028 (MIC >512 ug/ml or 92 uM), Streptococcus, S.aureus CICC10384 (MIC >512 ug/ml), and B.subtilis (MIC>512 ug/ml), and fungus P.pastoris X33 (512 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >512 µg/mL

Target

Target Organism S.aureus CICC10384

Source & Reference

Database Source Antifungipept

Other

Evidence Text

K88+ (MIC 11.5-23 uM), S.typhimurium ATCC14028 (MIC >512 ug/ml or 92 uM), Streptococcus, S.aureus CICC10384 (MIC >512 ug/ml), and B.subtilis (MIC>512 ug/ml), and fungus P.pastoris X33 (512 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >512 µg/mL

Target

Target Organism B.subtilis

Source & Reference

Database Source Antifungipept

Other

Evidence Text

C14028 (MIC >512 ug/ml or 92 uM), Streptococcus, S.aureus CICC10384 (MIC >512 ug/ml), and B.subtilis (MIC>512 ug/ml), and fungus P.pastoris X33 (512 ug/ml).