TPDB

3D PDB MODEL

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TPDB ID TPDB25931

Activity

Antibacterial

Activity_category_statistics

Anti-infective peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 13-aa standard natural antibacterial peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

TLKVVVKVVKYLV

FASTA

>TPDB25931|Antibacterial|length=13
TLKVVVKVVKYLV

Formula C73H130N16O16

Absent Amino Acids ARNDCEQGHIMFPSW

Common Amino Acids V

Mass 1487.93

PI 10.46

Basic Residues 3

Acidic Residues 0

Hydrophobic Residues 9

Net Charge +3

Boman Index 1.47

Hydrophobicity 1.469

Aliphatic Index 193.85

Half Life

Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 1490

Absorbance 280nm 100.14

Polar Residues 2

number

0

A

0

R

0

N

0

D

0

C

0

E

0

Q

0

G

0

H

0

I

2

L

3

K

0

M

0

F

0

P

0

S

1

T

0

W

1

Y

6

V

Amino Acid Distribution

A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 2 K: 3 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 6

Length

13

Formula

C73H130N16O16

Mass

1487.93

PI

10.46

Net Charge

+3

Boman Index

1.47

Hydrophobicity

1.469

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism B. cereus ATCC14579

Source & Reference

Database Source NA

Other

Evidence Text

us ATCC15975 (MRSA) (MIC 2 ug/ml), E. faecium LMG16003 (VRE), E. faecalis LMG16216 (VRE), B. cereus ATCC14579 (MIC 2 ug/ml), Gram- A. baumannii ATCC17978 (MIC 32 ug/ml), E. coli ATCC25922 (MIC 16 ug/ml), P. aerugi

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µg/mL

Target

Target Organism A. baumannii ATCC17978

Source & Reference

Database Source NA

Other

Evidence Text

cium LMG16003 (VRE), E. faecalis LMG16216 (VRE), B. cereus ATCC14579 (MIC 2 ug/ml), Gram- A. baumannii ATCC17978 (MIC 32 ug/ml), E. coli ATCC25922 (MIC 16 ug/ml), P. aeruginosa LMG6395 (MIC 64 ug/ml), and K. pneumonia

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16 µg/mL

Target

Target Organism Escherichia coli ATCC25922

Source & Reference

Database Source NA

Other

Evidence Text

16 (VRE), B. cereus ATCC14579 (MIC 2 ug/ml), Gram- A. baumannii ATCC17978 (MIC 32 ug/ml), E. coli ATCC25922 (MIC 16 ug/ml), P. aeruginosa LMG6395 (MIC 64 ug/ml), and K. pneumoniae LMG20218 (MIC 32 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µg/mL

Target

Target Organism Pseudomonas aeruginosa LMG6395

Source & Reference

Database Source NA

Other

Evidence Text

2 ug/ml), Gram- A. baumannii ATCC17978 (MIC 32 ug/ml), E. coli ATCC25922 (MIC 16 ug/ml), P. aeruginosa LMG6395 (MIC 64 ug/ml), and K. pneumoniae LMG20218 (MIC 32 ug/ml).

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 32 µg/mL

Target

Target Organism Klebsiella pneumoniae LMG20218

Source & Reference

Database Source NA

Other

Evidence Text

IC 32 ug/ml), E. coli ATCC25922 (MIC 16 ug/ml), P. aeruginosa LMG6395 (MIC 64 ug/ml), and K. pneumoniae LMG20218 (MIC 32 ug/ml).