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Peptide record

TPDB25920

Antibacterial Hemolysis Toxicity standard
13 amino acids
Basic Information
3D PDB MODEL
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TPDB25920
Antibacterial Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia Hemolytic2
standard
No
A 13-aa standard natural multi-activity (Antibacterial, Hemolysis, and Toxicity) peptide sequence curated from Peptipedia and Hemolytic2, with an available 3D structural model.
Sequence
TLKIIVKVVKYLV
Physicochemical Analysis
C75H134N16O16
ARNDCEQGHMFPSW
V
1515.99
10.46
3
0
9
+3
0.71
1.515
209.23
Mammalian: 7.2 hour Yeast: >20 hour E.coli: >10 hour
1490
98.29
2
Residue Composition
number
0
A
0
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
2
I
2
L
3
K
0
M
0
F
0
P
0
S
1
T
0
W
1
Y
4
V
Amino Acid Distribution
A: 0 R: 0 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 2 L: 2 K: 3 M: 0 F: 0 P: 0 S: 0 T: 1 W: 0 Y: 1 V: 4
Chemical Descriptors
13
C75H134N16O16
1515.99
10.46
+3
0.71
1.515
Evidence Records 21 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5-1.0 µg/mL

Target

A. acidoterrestris ATCC 49025

Source & Reference

NA

Other

Active against Gram+ A. acidoterrestris, A. acidoterrestris ATCC 49025 (MIC 0.5-1.0 ug/ml), B. cereus ATCC 11778 (MIC 2-4 ug/ml), B. cereus ATCC 14579 (MIC 1.0 ug/ml), C. difficile
Evidence 2 Activity

Activity

MIC
Antibacterial
2-4 µg/mL

Target

B. cereus ATCC 11778

Source & Reference

NA

Other

tive against Gram+ A. acidoterrestris, A. acidoterrestris ATCC 49025 (MIC 0.5-1.0 ug/ml), B. cereus ATCC 11778 (MIC 2-4 ug/ml), B. cereus ATCC 14579 (MIC 1.0 ug/ml), C. difficile A515 (MIC 4-8 ug/ml), E. faecalis ATC
Evidence 3 Activity

Activity

MIC
Antibacterial
1.0 µg/mL

Target

B. cereus ATCC 14579

Source & Reference

NA

Other

A. acidoterrestris ATCC 49025 (MIC 0.5-1.0 ug/ml), B. cereus ATCC 11778 (MIC 2-4 ug/ml), B. cereus ATCC 14579 (MIC 1.0 ug/ml), C. difficile A515 (MIC 4-8 ug/ml), E. faecalis ATCC 29212 (MIC 2 ug/ml), E. faecalis ATC
Evidence 4 Activity

Activity

MIC
Antibacterial
4-8 µg/mL

Target

Clostridioides difficile A515

Source & Reference

NA

Other

5-1.0 ug/ml), B. cereus ATCC 11778 (MIC 2-4 ug/ml), B. cereus ATCC 14579 (MIC 1.0 ug/ml), C. difficile A515 (MIC 4-8 ug/ml), E. faecalis ATCC 29212 (MIC 2 ug/ml), E. faecalis ATCC 51299 anti-VRE (MIC 4-8 ug/ml), L
Evidence 5 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

NA

Other

(MIC 2-4 ug/ml), B. cereus ATCC 14579 (MIC 1.0 ug/ml), C. difficile A515 (MIC 4-8 ug/ml), E. faecalis ATCC 29212 (MIC 2 ug/ml), E. faecalis ATCC 51299 anti-VRE (MIC 4-8 ug/ml), L. plantarum ATCC 8014 (MIC 2 ug/ml), L
Evidence 6 Activity

Activity

MIC
Antibacterial
4-8 µg/mL

Target

Enterococcus faecalis ATCC 51299 anti-VRE

Source & Reference

NA

Other

(MIC 1.0 ug/ml), C. difficile A515 (MIC 4-8 ug/ml), E. faecalis ATCC 29212 (MIC 2 ug/ml), E. faecalis ATCC 51299 anti-VRE (MIC 4-8 ug/ml), L. plantarum ATCC 8014 (MIC 2 ug/ml), L. lactis ATCC 11454 (MIC 2 ug/ml), L. innocua ATC
Evidence 7 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

L. plantarum ATCC 8014

Source & Reference

NA

Other

), E. faecalis ATCC 29212 (MIC 2 ug/ml), E. faecalis ATCC 51299 anti-VRE (MIC 4-8 ug/ml), L. plantarum ATCC 8014 (MIC 2 ug/ml), L. lactis ATCC 11454 (MIC 2 ug/ml), L. innocua ATCC 33090 (MIC 1-2 ug/ml), L. monocytoge
Evidence 8 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

L. lactis ATCC 11454

Source & Reference

NA

Other

), E. faecalis ATCC 51299 anti-VRE (MIC 4-8 ug/ml), L. plantarum ATCC 8014 (MIC 2 ug/ml), L. lactis ATCC 11454 (MIC 2 ug/ml), L. innocua ATCC 33090 (MIC 1-2 ug/ml), L. monocytogenes OSY-8578 (MIC 1-2 ug/ml), L. mon
Evidence 9 Activity

Activity

MIC
Antibacterial
1-2 µg/mL

Target

L. innocua ATCC 33090

Source & Reference

NA

Other

MIC 4-8 ug/ml), L. plantarum ATCC 8014 (MIC 2 ug/ml), L. lactis ATCC 11454 (MIC 2 ug/ml), L. innocua ATCC 33090 (MIC 1-2 ug/ml), L. monocytogenes OSY-8578 (MIC 1-2 ug/ml), L. monocytogenes Scott A (MIC 1 ug/ml), S. au
Evidence 10 Activity

Activity

MIC
Antibacterial
1-2 µg/mL

Target

L. monocytogenes OSY-8578

Source & Reference

NA

Other

(MIC 2 ug/ml), L. lactis ATCC 11454 (MIC 2 ug/ml), L. innocua ATCC 33090 (MIC 1-2 ug/ml), L. monocytogenes OSY-8578 (MIC 1-2 ug/ml), L. monocytogenes Scott A (MIC 1 ug/ml), S. aureus ATCC 6538, MRSA (MIC 1-2 ug/ml), Gram-
Evidence 11 Activity

Activity

MIC
Antibacterial
1 µg/mL

Target

L. monocytogenes Scott A

Source & Reference

NA

Other

ug/ml), L. innocua ATCC 33090 (MIC 1-2 ug/ml), L. monocytogenes OSY-8578 (MIC 1-2 ug/ml), L. monocytogenes Scott A (MIC 1 ug/ml), S. aureus ATCC 6538, MRSA (MIC 1-2 ug/ml), Gram- E-coli K-12 (MIC >32 ug/ml), E. coli O1
Evidence 12 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

v. campestris NCCB92058

Source & Reference

NA

Other

S-enterica serovar Typhimurium DT 109 (MIC >32 ug/ml). Also active against X. campestris pv. campestris NCCB92058 (MIC 2 ug/ml), X. translucens pv. graminis LMG587 (MIC 2 ug/ml), P. syringae pv. antirrhini LMG2131, P.
Evidence 13 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

v. graminis LMG587

Source & Reference

NA

Other

Also active against X. campestris pv. campestris NCCB92058 (MIC 2 ug/ml), X. translucens pv. graminis LMG587 (MIC 2 ug/ml), P. syringae pv. antirrhini LMG2131, P. syringae pv. tomato DC3000 (MIC 8-16 ug/ml), P. a
Evidence 14 Activity

Activity

MIC
Antibacterial
8-16 µg/mL

Target

v. tomato DC3000

Source & Reference

NA

Other

ucens pv. graminis LMG587 (MIC 2 ug/ml), P. syringae pv. antirrhini LMG2131, P. syringae pv. tomato DC3000 (MIC 8-16 ug/ml), P. aeruginosa PAO1 (MIC 32), K. pneumoniae LMG20218 (MIC 16 ug/ml), E. coli ET8 or MG166
Evidence 15 Activity

Activity

MIC
Antibacterial
16 µg/mL

Target

Klebsiella pneumoniae LMG20218

Source & Reference

NA

Other

ini LMG2131, P. syringae pv. tomato DC3000 (MIC 8-16 ug/ml), P. aeruginosa PAO1 (MIC 32), K. pneumoniae LMG20218 (MIC 16 ug/ml), E. coli ET8 or MG1665 (MIC 8-16 ug/ml), P.carotovorum LMG5863 (ND), R. syzygii subsp. sy
Evidence 16 Activity

Activity

MIC
Antibacterial
8-16 µg/mL

Target

Escherichia coli ET8 or MG1665

Source & Reference

NA

Other

000 (MIC 8-16 ug/ml), P. aeruginosa PAO1 (MIC 32), K. pneumoniae LMG20218 (MIC 16 ug/ml), E. coli ET8 or MG1665 (MIC 8-16 ug/ml), P.carotovorum LMG5863 (ND), R. syzygii subsp. syzygii LMG6969 (ND), S. aureus subsp. aur
Evidence 17 Activity

Activity

MIC
Antibacterial
1-2 µg/mL

Target

B. cereus ATCC14579

Source & Reference

NA

Other

us ATCC15975 (MRSA) (MIC 2 ug/ml), E. faecium LMG16003 (VRE), E. faecalis LMG16216 (VRE), B. cereus ATCC14579 (MIC 1-2 ug/ml), Gram- A. baumannii ATCC17978 (MIC 32 ug/ml), E. coli ATCC25922 (MIC 32 ug/ml), P. aerugi
Evidence 18 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

A. baumannii ATCC17978

Source & Reference

NA

Other

um LMG16003 (VRE), E. faecalis LMG16216 (VRE), B. cereus ATCC14579 (MIC 1-2 ug/ml), Gram- A. baumannii ATCC17978 (MIC 32 ug/ml), E. coli ATCC25922 (MIC 32 ug/ml), P. aeruginosa LMG6395 (MIC 64 ug/ml), and K. pneumonia
Evidence 19 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

Escherichia coli ATCC25922

Source & Reference

NA

Other

(VRE), B. cereus ATCC14579 (MIC 1-2 ug/ml), Gram- A. baumannii ATCC17978 (MIC 32 ug/ml), E. coli ATCC25922 (MIC 32 ug/ml), P. aeruginosa LMG6395 (MIC 64 ug/ml), and K. pneumoniae LMG20218 (MIC 32 ug/ml).
Evidence 20 Activity

Activity

MIC
Antibacterial
64 µg/mL

Target

Pseudomonas aeruginosa LMG6395

Source & Reference

NA

Other

-2 ug/ml), Gram- A. baumannii ATCC17978 (MIC 32 ug/ml), E. coli ATCC25922 (MIC 32 ug/ml), P. aeruginosa LMG6395 (MIC 64 ug/ml), and K. pneumoniae LMG20218 (MIC 32 ug/ml).
Evidence 21 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

Klebsiella pneumoniae LMG20218

Source & Reference

NA

Other

IC 32 ug/ml), E. coli ATCC25922 (MIC 32 ug/ml), P. aeruginosa LMG6395 (MIC 64 ug/ml), and K. pneumoniae LMG20218 (MIC 32 ug/ml).