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Peptide record

TPDB25850

Antibacterial Anticancer Antifungal Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB25850
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia AFP-GFuse
standard
No
A 38-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and AFP-GFuse, with an available 3D structural model.
Sequence
SYYSTLQCRNNHGHCRRLCFHGEQWIGNCNGRHQHCCK
Physicochemical Analysis
C188H281N69O53S6
ADMPV
C
4548.09
8.59
10
1
7
+4
7.18
-1.142
30.79
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
8855
194.70
18
Residue Composition
number
0
A
4
R
4
N
0
D
6
C
1
E
3
Q
4
G
5
H
1
I
2
L
1
K
0
M
1
F
0
P
2
S
1
T
1
W
2
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 4 D: 0 C: 6 E: 1 Q: 3 G: 4 H: 5 I: 1 L: 2 K: 1 M: 0 F: 1 P: 0 S: 2 T: 1 W: 1 Y: 2 V: 0
Chemical Descriptors
38
C188H281N69O53S6
4548.09
8.59
+4
7.18
-1.142
Evidence Records 4 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

inhibited C. albicans (MIC 5 uM IC50 4.1uM).
Evidence 2 Activity

Activity

Antifungal

Source & Reference

NA

Other

inhibited C. albicans (MIC 5 uM IC50 4.1uM).
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Crocodile defensin (CpoBD13) antifungal activity via pH-dependent phospholipid targeting and membrane disruption. | Nat Commun | 2023
Evidence 4 Activity

Activity

30 % Cell death
Toxicity
100 µM
Cytotoxic
30 % Cell death | 100 | µM | target cell: Human umbilical vein endothelial cells HUVEC

Target

Human umbilical vein endothelial cells HUVEC

Source & Reference

NA
DBAASP
Crocodile defensin (CpoBD13) antifungal activity via pH-dependent phospholipid targeting and membrane disruption. | Nat Commun | 2023