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Peptide record

TPDB25841

Antibacterial Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB25841
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 31-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
SWLSKTYKKLENSAKKRIAEGIAIALRGGPR
Physicochemical Analysis
C154H261N47O42
DCQHMFV
K
3443.06
11.09
8
2
12
+6
6.77
-0.629
88.39
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
6990
203.02
6
Residue Composition
number
4
A
3
R
1
N
0
D
0
C
2
E
0
Q
3
G
0
H
3
I
3
L
5
K
0
M
0
F
1
P
3
S
1
T
1
W
1
Y
0
V
Amino Acid Distribution
A: 4 R: 3 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 3 H: 0 I: 3 L: 3 K: 5 M: 0 F: 0 P: 1 S: 3 T: 1 W: 1 Y: 1 V: 0
Chemical Descriptors
31
C154H261N47O42
3443.06
11.09
+6
6.77
-0.629
Evidence Records 4 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1-2 µM

Target

i.2

Source & Reference

NA

Other

Active against E. coli ATCC, c.i., or c.i.2 (MIC 1-2 uM), K. pneumoniae ATCC, c.i., c.i.2 (MIC 0.5-4 uM), A. baumannii ATCC, c.i., or c.i.2. (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
0.5-4 µM

Target

i.2

Source & Reference

NA

Other

Active against E. coli ATCC, c.i., or c.i.2 (MIC 1-2 uM), K. pneumoniae ATCC, c.i., c.i.2 (MIC 0.5-4 uM), A. baumannii ATCC, c.i., or c.i.2. (MIC 1 uM), P. aeruginosa ATCC, c.i., or c.i.2 (MIC 4
Evidence 3 Activity

Activity

MIC
Antibacterial
4-8 µM

Target

i.2

Source & Reference

NA

Other

0.5-4 uM), A. baumannii ATCC, c.i., or c.i.2. (MIC 1 uM), P. aeruginosa ATCC, c.i., or c.i.2 (MIC 4-8 uM), and S. aureus ATCC, c.i., or c.i.2 (MIC 16-32 or >64 uM). All MBC values are similar to
Evidence 4 Activity

Activity

LC50
Toxicity
78 µM
Cytotoxic
LC50 | 78 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Anisaxins, helical antimicrobial peptides from marine parasites, kill resistant bacteria by lipid extraction and membrane disruption. | Acta Biomater | 2022