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Peptide record

TPDB25840

Antibacterial Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB25840
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 31-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
SWLSKTWKKLENSGKKRIAEGIAIALKGGLR
Physicochemical Analysis
C156H264N46O41
DCQHMFPYV
K
3440.10
11.16
8
2
12
+6
5.21
-0.494
97.74
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
11000
319.76
5
Residue Composition
number
3
A
2
R
1
N
0
D
0
C
2
E
0
Q
4
G
0
H
3
I
4
L
6
K
0
M
0
F
0
P
3
S
1
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 3 R: 2 N: 1 D: 0 C: 0 E: 2 Q: 0 G: 4 H: 0 I: 3 L: 4 K: 6 M: 0 F: 0 P: 0 S: 3 T: 1 W: 2 Y: 0 V: 0
Chemical Descriptors
31
C156H264N46O41
3440.10
11.16
+6
5.21
-0.494
Evidence Records 6 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5-1 µM

Target

i.2

Source & Reference

NA

Other

Active against E. coli ATCC, c.i. or c.i.2 (MIC 0.5-1 uM), K. pneumoniae ATCC, c.i., c.i.2 (MIC 0.25-1 uM), A. baumannii ATCC, c.i., or c.i.2. (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
0.25-1 µM

Target

i.2

Source & Reference

NA

Other

Active against E. coli ATCC, c.i. or c.i.2 (MIC 0.5-1 uM), K. pneumoniae ATCC, c.i., c.i.2 (MIC 0.25-1 uM), A. baumannii ATCC, c.i., or c.i.2. (MIC 0.25-0.5 uM), P. aeruginosa ATCC, c.i., or c.i.2
Evidence 3 Activity

Activity

MIC
Antibacterial
1-8 µM

Target

i.2

Source & Reference

NA

Other

uM), A. baumannii ATCC, c.i., or c.i.2. (MIC 0.25-0.5 uM), P. aeruginosa ATCC, c.i., or c.i.2 (MIC 1-8 uM), and S. aureus ATCC (MIC 4 uM), S-aureus c.i., or c.i.2 (MIC >64 uM). All MBC values are
Evidence 4 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus ATCC

Source & Reference

NA

Other

, c.i., or c.i.2. (MIC 0.25-0.5 uM), P. aeruginosa ATCC, c.i., or c.i.2 (MIC 1-8 uM), and S. aureus ATCC (MIC 4 uM), S-aureus c.i., or c.i.2 (MIC >64 uM). All MBC values are similar to MIC values, indicati
Evidence 5 Activity

Activity

MIC
Antibacterial
>64 µM

Target

i.2

Source & Reference

NA

Other

osa ATCC, c.i., or c.i.2 (MIC 1-8 uM), and S. aureus ATCC (MIC 4 uM), S-aureus c.i., or c.i.2 (MIC >64 uM). All MBC values are similar to MIC values, indicative of a bactericidal effect.
Evidence 6 Activity

Activity

LC50
Toxicity
>100 µM
Cytotoxic
LC50 | >100 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Anisaxins, helical antimicrobial peptides from marine parasites, kill resistant bacteria by lipid extraction and membrane disruption. | Acta Biomater | 2022