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Peptide record

TPDB25837

Antibacterial Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB25837
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 31-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
SWLSKTAKKLENSAKKRIAEGIAIAIQGGPR
Physicochemical Analysis
C147H253N45O42
DCHMFYV
AK
3322.90
11.08
7
2
12
+5
7.56
-0.474
91.61
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5500
165.52
6
Residue Composition
number
5
A
2
R
1
N
0
D
0
C
2
E
1
Q
3
G
0
H
4
I
2
L
5
K
0
M
0
F
1
P
3
S
1
T
1
W
0
Y
0
V
Amino Acid Distribution
A: 5 R: 2 N: 1 D: 0 C: 0 E: 2 Q: 1 G: 3 H: 0 I: 4 L: 2 K: 5 M: 0 F: 0 P: 1 S: 3 T: 1 W: 1 Y: 0 V: 0
Chemical Descriptors
31
C147H253N45O42
3322.90
11.08
+5
7.56
-0.474
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.5-1 µM

Target

i.2

Source & Reference

NA

Other

Active against E. coli ATCC, c.i., or c.i.2 (MIC 0.5-1 uM), K. pneumoniae ATCC, c.i., c.i.2 (MIC 0.5-2 uM), A. baumannii ATCC, c.i., or c.i.2. (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
0.5-2 µM

Target

i.2

Source & Reference

NA

Other

Active against E. coli ATCC, c.i., or c.i.2 (MIC 0.5-1 uM), K. pneumoniae ATCC, c.i., c.i.2 (MIC 0.5-2 uM), A. baumannii ATCC, c.i., or c.i.2. (MIC 0.25-0.5 uM), P. aeruginosa ATCC, c.i., or c.i.2
Evidence 3 Activity

Activity

MIC
Antibacterial
4-32 µM

Target

i.2

Source & Reference

NA

Other

uM), A. baumannii ATCC, c.i., or c.i.2. (MIC 0.25-0.5 uM), P. aeruginosa ATCC, c.i., or c.i.2 (MIC 4-32 uM), and S-aureus ATCC c.i., or c.i.2 (MIC >64 uM). All MBC values are similar to MIC values,
Evidence 4 Activity

Activity

MIC
Antibacterial
>64 µM

Target

i.2

Source & Reference

NA

Other

5-0.5 uM), P. aeruginosa ATCC, c.i., or c.i.2 (MIC 4-32 uM), and S-aureus ATCC c.i., or c.i.2 (MIC >64 uM). All MBC values are similar to MIC values, indicative of a bactericidal effect.
Evidence 5 Activity

Activity

LC50
Toxicity
21 µM
Cytotoxic
LC50 | 21 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Anisaxins, helical antimicrobial peptides from marine parasites, kill resistant bacteria by lipid extraction and membrane disruption. | Acta Biomater | 2022