TPDB

3D PDB MODEL

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TPDB ID TPDB25730

Activity

Antibacterial Anticancer Antifungal

Activity_category_statistics

Anti-infective peptides Cancer-related peptides

Database_Source

Peptipedia CancerPPD 2.0 dbACP Antifungipept

Sequence_Type

standard

Has_Modification No

Description A 41-aa standard natural multi-activity (Antibacterial, Anticancer, and Antifungal) peptide sequence curated from Peptipedia, CancerPPD 2.0, dbACP, and other sources, with an available 3D structural model.

Sequence

SPRVRRRYGRPFGGRPFVGGQFGGRPGCVCIRSPCPCANYG

FASTA

>TPDB25730|Antibacterial;Anticancer;Antifungal|length=41
SPRVRRRYGRPFGGRPFVGGQFGGRPGCVCIRSPCPCANYG

Formula C192H299N67O48S4

Absent Amino Acids DEHLKMTW

Common Amino Acids G

Mass 4442.15

PI 11.59

Basic Residues 8

Acidic Residues 0

Hydrophobic Residues 10

Net Charge +8

Boman Index 4.03

Hydrophobicity -0.563

Aliphatic Index 33.17

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 3230

Absorbance 280nm 72.71

Polar Residues 10

number

1

A

8

R

1

N

0

D

4

C

0

E

1

Q

9

G

0

H

1

I

0

L

0

K

0

M

3

F

6

P

2

S

0

T

0

W

2

Y

3

V

Amino Acid Distribution

A: 1 R: 8 N: 1 D: 0 C: 4 E: 0 Q: 1 G: 9 H: 0 I: 1 L: 0 K: 0 M: 0 F: 3 P: 6 S: 2 T: 0 W: 0 Y: 2 V: 3

Length

41

Formula

C192H299N67O48S4

Mass

4442.15

PI

11.59

Net Charge

+8

Boman Index

4.03

Hydrophobicity

-0.563

Evidence 1 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 20 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Recombinant rSs-arasin showed antimicrobial activity against S. aureus (IC50 20 uM), P. aeruginosa (IC50 40 uM), and E. coli (IC50 20 uM). It also inhibited human cervical c

Evidence 2 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 40 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source NA

Other

Evidence Text

Recombinant rSs-arasin showed antimicrobial activity against S. aureus (IC50 20 uM), P. aeruginosa (IC50 40 uM), and E. coli (IC50 20 uM). It also inhibited human cervical carcinoma (HeLa, IC50 3.06 uM

Evidence 3 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antibacterial

Activity Measurement 20 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source NA

Other

Evidence Text

ed antimicrobial activity against S. aureus (IC50 20 uM), P. aeruginosa (IC50 40 uM), and E. coli (IC50 20 uM). It also inhibited human cervical carcinoma (HeLa, IC50 3.06 uM) and colon carcinoma (HT-

Evidence 4 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 20 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Recombinant rSs-arasin showed antimicrobial activity against S. aureus (IC50 20 uM), P. aeruginosa (IC50 40 uM), and E. coli (IC50 20 uM). It also inhibited human cervical c

Evidence 5 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 40 µM

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source Antifungipept

Other

Evidence Text

Recombinant rSs-arasin showed antimicrobial activity against S. aureus (IC50 20 uM), P. aeruginosa (IC50 40 uM), and E. coli (IC50 20 uM). It also inhibited human cervical carcinoma (HeLa, IC50 3.06 uM

Evidence 6 Activity

Activity

Activity Endpoint IC50

Detail Source Activity Antifungal

Activity Measurement 20 µM

Target

Target Organism Escherichia coli

Source & Reference

Database Source Antifungipept

Other

Evidence Text

ed antimicrobial activity against S. aureus (IC50 20 uM), P. aeruginosa (IC50 40 uM), and E. coli (IC50 20 uM). It also inhibited human cervical carcinoma (HeLa, IC50 3.06 uM) and colon carcinoma (HT-