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Peptide record

TPDB25729

Antibacterial Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB25729
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia ToxinPred 3.0
standard
No
A 20-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia and ToxinPred 3.0, with an available 3D structural model.
Sequence
SPRVCIRVCRNGVCYRRCWG
Physicochemical Analysis
C99H163N37O24S4
ADEQHLKMFT
R
2383.86
9.95
5
0
6
+5
1.22
-0.215
63.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
7240
303.71
7
Residue Composition
number
0
A
5
R
1
N
0
D
4
C
0
E
0
Q
2
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
1
S
0
T
1
W
1
Y
3
V
Amino Acid Distribution
A: 0 R: 5 N: 1 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 1 V: 3
Chemical Descriptors
20
C99H163N37O24S4
2383.86
9.95
+5
1.22
-0.215
Evidence Records 10 records
Evidence 1 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus aureus ATCC 6538P

Source & Reference

NA

Other

active against Gram+ S. aureus ATCC 6538P (MIC 8 uM), M. luteus B-1314 (MIC 4 uM), B. subtilis B-886 (MIC 16 uM), Gram- E. coli ATTC 25922 or
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

M. luteus B-1314

Source & Reference

NA

Other

active against Gram+ S. aureus ATCC 6538P (MIC 8 uM), M. luteus B-1314 (MIC 4 uM), B. subtilis B-886 (MIC 16 uM), Gram- E. coli ATTC 25922 or ML-35p or CI 214 or MDR CI 10
Evidence 3 Activity

Activity

MIC
Antibacterial
16 µM

Target

B. subtilis B-886

Source & Reference

NA

Other

active against Gram+ S. aureus ATCC 6538P (MIC 8 uM), M. luteus B-1314 (MIC 4 uM), B. subtilis B-886 (MIC 16 uM), Gram- E. coli ATTC 25922 or ML-35p or CI 214 or MDR CI 1057 or MDR CI 3600 (MIC 0.125-0.
Evidence 4 Activity

Activity

MIC
Antibacterial
0.125-0.5 µM

Target

Escherichia coli ATTC 25922 or ML-35p or CI 214 or MDR CI 1057 or MDR CI 3600

Source & Reference

NA

Other

ATCC 6538P (MIC 8 uM), M. luteus B-1314 (MIC 4 uM), B. subtilis B-886 (MIC 16 uM), Gram- E. coli ATTC 25922 or ML-35p or CI 214 or MDR CI 1057 or MDR CI 3600 (MIC 0.125-0.5 uM), E. cloacae XDR CI 4172 (MIC 4 uM), A. baumanii XDR CI 2675 or XDR CI 450 (MIC 0.25-0.5 u
Evidence 5 Activity

Activity

MIC
Antibacterial
4 µM

Target

Enterobacter cloacae XDR CI 4172

Source & Reference

NA

Other

E. coli ATTC 25922 or ML-35p or CI 214 or MDR CI 1057 or MDR CI 3600 (MIC 0.125-0.5 uM), E. cloacae XDR CI 4172 (MIC 4 uM), A. baumanii XDR CI 2675 or XDR CI 450 (MIC 0.25-0.5 uM), K. pneumonia ATCC 700603 or MDR
Evidence 6 Activity

Activity

MIC
Antibacterial
0.25-0.5 µM

Target

A. baumanii XDR CI 2675 or XDR CI 450

Source & Reference

NA

Other

214 or MDR CI 1057 or MDR CI 3600 (MIC 0.125-0.5 uM), E. cloacae XDR CI 4172 (MIC 4 uM), A. baumanii XDR CI 2675 or XDR CI 450 (MIC 0.25-0.5 uM), K. pneumonia ATCC 700603 or MDR CI 358 or XDR CI 1056 or XDR CI 3395 (MIC 2-4 uM), P. ae
Evidence 7 Activity

Activity

MIC
Antibacterial
2-4 µM

Target

K. pneumonia ATCC 700603 or MDR CI 358 or XDR CI 1056 or XDR CI 3395

Source & Reference

NA

Other

cloacae XDR CI 4172 (MIC 4 uM), A. baumanii XDR CI 2675 or XDR CI 450 (MIC 0.25-0.5 uM), K. pneumonia ATCC 700603 or MDR CI 358 or XDR CI 1056 or XDR CI 3395 (MIC 2-4 uM), P. aeruginosa ATCC 27853 or PAO1 or MDR CI 223 or XDR CI 236 or XDR CI 1049 or XDR CI 19
Evidence 8 Activity

Activity

MIC
Antibacterial
2-8 µM

Target

Pseudomonas aeruginosa ATCC 27853 or PAO1 or MDR CI 223 or XDR CI 236 or XDR CI 1049 or XDR CI 1995 metallo-beta-lactamase producing strain

Source & Reference

NA

Other

5 uM), K. pneumonia ATCC 700603 or MDR CI 358 or XDR CI 1056 or XDR CI 3395 (MIC 2-4 uM), P. aeruginosa ATCC 27853 or PAO1 or MDR CI 223 or XDR CI 236 or XDR CI 1049 or XDR CI 1995 metallo-beta-lactamase producing strain (MIC 2-8 uM), and S-marcescens MDR CI 1689 (MIC >32 uM). CI=clinical isolates MDR, multidrug resistan
Evidence 9 Activity

Activity

<5% Hemolysis
Toxicity
64 µM
Hemolytic Cytotoxic
<5% Hemolysis | 64 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Structure Elucidation and Functional Studies of a Novel β-hairpin Antimicrobial Peptide from the Marine Polychaeta Capitella teleta. | Mar Drugs | 2020
Evidence 10 Activity

Activity

20% Killing
Toxicity
64 µM
Cytotoxic
20% Killing | 64 | µM | target cell: Human embryonic fibroblasts

Target

Human embryonic fibroblasts

Source & Reference

NA
DBAASP
Structure Elucidation and Functional Studies of a Novel β-hairpin Antimicrobial Peptide from the Marine Polychaeta Capitella teleta. | Mar Drugs | 2020