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Peptide record

TPDB25728

Antibacterial Toxicity standard
19 amino acids
Basic Information
3D PDB MODEL
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TPDB25728
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 19-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
SPRVCIRVCRNGVCYRRCW
Physicochemical Analysis
C97H160N36O23S4
ADEQHLKMFT
R
2326.81
9.95
5
0
6
+5
1.21
-0.205
66.32
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
7240
311.16
7
Residue Composition
number
0
A
5
R
1
N
0
D
4
C
0
E
0
Q
1
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
1
S
0
T
1
W
1
Y
3
V
Amino Acid Distribution
A: 0 R: 5 N: 1 D: 0 C: 4 E: 0 Q: 0 G: 1 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 1 V: 3
Chemical Descriptors
19
C97H160N36O23S4
2326.81
9.95
+5
1.21
-0.205
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4 µM

Target

M. luteus B-1314

Source & Reference

NA

Other

active against Gram+ M. luteus B-1314 (MIC 4 uM), S. aureus 209P (MIC 8 uM), B. subtilis B-886 (MIC 32 uM), E. coli ML-35p or ATTC 25922 o
Evidence 2 Activity

Activity

MIC
Antibacterial
8 µM

Target

Staphylococcus aureus 209P

Source & Reference

NA

Other

active against Gram+ M. luteus B-1314 (MIC 4 uM), S. aureus 209P (MIC 8 uM), B. subtilis B-886 (MIC 32 uM), E. coli ML-35p or ATTC 25922 or CI 3600 or CI 214 (MIC 0.
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µM

Target

B. subtilis B-886

Source & Reference

NA

Other

active against Gram+ M. luteus B-1314 (MIC 4 uM), S. aureus 209P (MIC 8 uM), B. subtilis B-886 (MIC 32 uM), E. coli ML-35p or ATTC 25922 or CI 3600 or CI 214 (MIC 0.5-1 uM), E. cloacae CI 4172 (MI
Evidence 4 Activity

Activity

MIC
Antibacterial
0.5-1 µM

Target

Escherichia coli ML-35p or ATTC 25922 or CI 3600 or CI 214

Source & Reference

NA

Other

m+ M. luteus B-1314 (MIC 4 uM), S. aureus 209P (MIC 8 uM), B. subtilis B-886 (MIC 32 uM), E. coli ML-35p or ATTC 25922 or CI 3600 or CI 214 (MIC 0.5-1 uM), E. cloacae CI 4172 (MIC 8 uM), A. baumanii CI 2675 (MIC 0.25 uM), P. aeruginosa PAO1 (MI
Evidence 5 Activity

Activity

MIC
Antibacterial
8 µM

Target

Enterobacter cloacae CI 4172

Source & Reference

NA

Other

ilis B-886 (MIC 32 uM), E. coli ML-35p or ATTC 25922 or CI 3600 or CI 214 (MIC 0.5-1 uM), E. cloacae CI 4172 (MIC 8 uM), A. baumanii CI 2675 (MIC 0.25 uM), P. aeruginosa PAO1 (MIC 2 uM), and K. pneumonia ATCC
Evidence 6 Activity

Activity

MIC
Antibacterial
0.25 µM

Target

A. baumanii CI 2675

Source & Reference

NA

Other

ML-35p or ATTC 25922 or CI 3600 or CI 214 (MIC 0.5-1 uM), E. cloacae CI 4172 (MIC 8 uM), A. baumanii CI 2675 (MIC 0.25 uM), P. aeruginosa PAO1 (MIC 2 uM), and K. pneumonia ATCC 700603 (MIC 4 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
2 µM

Target

Pseudomonas aeruginosa PAO1

Source & Reference

NA

Other

CI 214 (MIC 0.5-1 uM), E. cloacae CI 4172 (MIC 8 uM), A. baumanii CI 2675 (MIC 0.25 uM), P. aeruginosa PAO1 (MIC 2 uM), and K. pneumonia ATCC 700603 (MIC 4 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
4 µM

Target

K. pneumonia ATCC 700603

Source & Reference

NA

Other

CI 4172 (MIC 8 uM), A. baumanii CI 2675 (MIC 0.25 uM), P. aeruginosa PAO1 (MIC 2 uM), and K. pneumonia ATCC 700603 (MIC 4 uM).
Evidence 9 Activity

Activity

<5% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
<5% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Mechanism of Action and Therapeutic Potential of the β-Hairpin Antimicrobial Peptide Capitellacin from the Marine Polychaeta Capitella teleta | Mar Drugs | 2022