TPDB

3D PDB MODEL

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TPDB ID TPDB25716

Peptide_Name

Brain natriuretic peptide 32

Activity

Antibacterial Anticancer Antifungal Antiparasitic Neuropeptide

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Neuroactive peptides

Database_Source

Peptipedia PEPlife

Sequence_Type

standard

Has_Modification No

Description A 32-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and PEPlife, with an available 3D structural model.

Sequence

SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH

FASTA

>TPDB25716|Antibacterial;Anticancer;Antifungal;Antiparasitic;Neuropeptide|length=32
SPKMVQGSGCFGRKMDRISSSSGLGCKVLRRH

Formula C143H246N50O42S4

Absent Amino Acids ANETWY

Common Amino Acids S

Mass 3466.08

PI 11.40

Basic Residues 8

Acidic Residues 1

Hydrophobic Residues 8

Net Charge +6

Boman Index 6.90

Hydrophobicity -0.506

Aliphatic Index 54.69

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 3.61

Polar Residues 9

number

0

A

4

R

0

N

1

D

2

C

0

E

1

Q

5

G

1

H

1

I

2

L

3

K

2

M

1

F

1

P

6

S

0

T

0

W

0

Y

2

V

Amino Acid Distribution

A: 0 R: 4 N: 0 D: 1 C: 2 E: 0 Q: 1 G: 5 H: 1 I: 1 L: 2 K: 3 M: 2 F: 1 P: 1 S: 6 T: 0 W: 0 Y: 0 V: 2

Length

32

Formula

C143H246N50O42S4

Mass

3466.08

PI

11.40

Net Charge

+6

Boman Index

6.90

Hydrophobicity

-0.506

Evidence 1 Activity

Activity

Detail Source Activity Neuropeptide

Target

Receptor Names Atrial natriuretic peptide receptor 1 Atrial natriuretic peptide receptor 3

Receptor Organisms Homo sapiens Homo sapiens

Source & Reference

Database Source NA

Source NeuroPepV2

Other

Organism Source Homo sapiens

Family Natriuretic peptide

Receptor Lengths 1061 541

Receptor Ligands NP06438 NP06449 NP06460 NP06471 NP06482 NP06493 NP06504 NP06515 NP06522 NP06523 NP06524 NP06525 NP06526 NP06527 NP06528 NP06529 NP06530 NP06531 NP06532 NP06533 NP06534 NP06535 NP06588 NP06591 NP06665 NP06682 NP06735 NP06744 NP06750 NP06759 NP06767 NP06790 NP06438 NP06449 NP06460 NP06471 NP06482 NP06493 NP06504 NP06515 NP06522 NP06523 NP06524 NP06525 NP06526 NP06527 NP06528 NP06529 NP06530 NP06531 NP06532 NP06533 NP06534 NP06535 NP06588 NP06591 NP06665 NP06682 NP06735 NP06744 NP06750 NP06759 NP06767 NP06790 NP06598 NP06606 NP06616

Experiment context

Approx. 18 mins

Family

Natriuretic peptide

Half-life seconds

1080.0

Half-life unit

mins

Hydrophobicity

N.A.

Molecular Weight (Daltons)

3464

pI

N.A.

Receptor_Lengths

1061 541

Receptor_Ligands

NP06438 NP06449 NP06460 NP06471 NP06482 NP06493 NP06504 NP06515 NP06522 NP06523 NP06524 NP06525 NP06526 NP06527 NP06528 NP06529 NP06530 NP06531 NP06532 NP06533 NP06534 NP06535 NP06588 NP06591 NP06665 NP06682 NP06735 NP06744 NP06750 NP06759 NP06767 NP06790 NP06598 NP06606 NP06616