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Peptide record

TPDB25700

Antibacterial Anticancer Antifungal Antiviral Toxicity standard
121 amino acids
Basic Information
3D PDB MODEL
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TPDB25700
Antibacterial Anticancer Antifungal Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia Antifungipept dbAMP 3.0
standard
No
A 121-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, Antifungipept, and dbAMP 3.0, with an available 3D structural model.
Sequence
SLTHRKFGGSGGSPFSGLSSIAVRSGSYLDAIIIDGVHHGGSGGNLSPTFTFGSGEYISNMTIRSGDYIDNISFETNMGRRFGPYGGSGGSANTLSNVKVIQINGSAGDYLDSLDIYYEQY
Physicochemical Analysis
C557H843N153O184S2
CW
G
12690.85
5.30
10
10
42
-3
10.07
-0.240
70.91
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
11920
93.93
42
Residue Composition
number
4
A
5
R
7
N
7
D
0
C
3
E
2
Q
22
G
3
H
11
I
7
L
2
K
2
M
6
F
3
P
19
S
6
T
0
W
8
Y
4
V
Amino Acid Distribution
A: 4 R: 5 N: 7 D: 7 C: 0 E: 3 Q: 2 G: 22 H: 3 I: 11 L: 7 K: 2 M: 2 F: 6 P: 3 S: 19 T: 6 W: 0 Y: 8 V: 4
Chemical Descriptors
121
C557H843N153O184S2
12690.85
5.30
-3
10.07
-0.240
Evidence Records 12 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

It binds multiple mannose-rich glycans on HIV-1 gp120 (Alexandre KB et al., 2013) . You can rotate, zoom, and view the 3D structure here in the PDB . Updated 2/2014.
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

It binds multiple mannose-rich glycans on HIV-1 gp120 (Alexandre KB et al., 2013) . You can rotate, zoom, and view the 3D structure here in the PDB . Updated 2/2014.
Evidence 3 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
It binds multiple mannose-rich glycans on HIV-1 gp120 (Alexandre KB et al., 2013) . You can rotate, zoom, and view the 3D structure here in the PDB . Updated 2/2014.
Evidence 4 Activity

Activity

IC50
Toxicity
68 µg/mL
Cytotoxic
IC50 | 68 | µg/mL | target cell: Chicken Embryonic Fibroblasts (CEF)

Target

Chicken Embryonic Fibroblasts (CEF)

Source & Reference

NA
DBAASP
Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. | J Virol | 2010
Evidence 5 Activity

Activity

IC50
Toxicity
0.44 µg/mL
Cytotoxic
IC50 | 0.44 | µg/mL | target cell: Mouse embryonic liver cells BNL

Target

Mouse embryonic liver cells BNL

Source & Reference

NA
DBAASP
Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. | J Virol | 2010
Evidence 6 Activity

Activity

IC50
Toxicity
57 µg/mL
Cytotoxic
IC50 | 57 | µg/mL | target cell: Swine testis cells ST

Target

Swine testis cells ST

Source & Reference

NA
DBAASP
Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. | J Virol | 2010
Evidence 7 Activity

Activity

IC50
Toxicity
>10 µg/mL
Cytotoxic
IC50 | >10 | µg/mL | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. | J Virol | 2010
Evidence 8 Activity

Activity

IC50
Toxicity
10 µg/mL
Cytotoxic
IC50 | 10 | µg/mL | target cell: Monkey kidney epithelial cells LLC-MK2

Target

Monkey kidney epithelial cells LLC-MK2

Source & Reference

NA
DBAASP
Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. | J Virol | 2010
Evidence 9 Activity

Activity

IC50
Toxicity
>100 µg/mL
Cytotoxic
IC50 | >100 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Broad-spectrum in vitro activity and in vivo efficacy of the antiviral protein griffithsin against emerging viruses of the family Coronaviridae. | J Virol | 2010
Evidence 10 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: CEM-SS cells

Target

CEM-SS cells

Source & Reference

NA
DBAASP
Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp. | J Biol Chem | 2005
Evidence 11 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp. | J Biol Chem | 2005
Evidence 12 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human monocyte-derived macrophages

Target

Human monocyte-derived macrophages

Source & Reference

NA
DBAASP
Isolation and characterization of griffithsin, a novel HIV-inactivating protein, from the red alga Griffithsia sp. | J Biol Chem | 2005