TPDB

3D PDB MODEL

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TPDB ID TPDB25699

Activity

Antibacterial Anticancer Antiviral Toxicity

Activity_category_statistics

Anti-infective peptides Cancer-related peptides Toxicity and safety peptides

Database_Source

Peptipedia ToxinPred 3.0

Sequence_Type

standard

Has_Modification No

Description A 23-aa standard natural multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from Peptipedia and ToxinPred 3.0, with an available 3D structural model.

Sequence

SMLLLFFLGTISLSLCQDDQERC

FASTA

>TPDB25699|Antibacterial;Anticancer;Antiviral;Toxicity|length=23
SMLLLFFLGTISLSLCQDDQERC

Formula C115H186N28O36S3

Absent Amino Acids ANHKPWYV

Common Amino Acids L

Mass 2633.09

PI 3.70

Basic Residues 1

Acidic Residues 3

Hydrophobic Residues 10

Net Charge -2

Boman Index 0.35

Hydrophobicity 0.622

Aliphatic Index 118.70

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 125

Absorbance 280nm 4.75

Polar Residues 8

number

0

A

1

R

0

N

2

D

2

C

1

E

2

Q

1

G

0

H

1

I

6

L

0

K

1

M

2

F

0

P

3

S

1

T

0

W

0

Y

0

V

Amino Acid Distribution

A: 0 R: 1 N: 0 D: 2 C: 2 E: 1 Q: 2 G: 1 H: 0 I: 1 L: 6 K: 0 M: 1 F: 2 P: 0 S: 3 T: 1 W: 0 Y: 0 V: 0

Length

23

Formula

C115H186N28O36S3

Mass

2633.09

PI

3.70

Net Charge

-2

Boman Index

0.35

Hydrophobicity

0.622

Evidence 1 Activity

Activity

Detail Source Activity Antibacterial

Source & Reference

Database Source NA

Other

Evidence Text

The peptide is virucidal against both Zika virus (ZIKV) (D=L) and dengue viruses (DENV). Yodha peptide efficiently inhibited DENV1 (IC50 25 uM), DENV2 (IC50 2 uM), DENV3 (IC50 70 uM), and DENV4 (IC50 30 uM).

Evidence 2 Activity

Activity

Detail Source Activity Antiviral

Source & Reference

Database Source NA

Other

Evidence Text

The peptide is virucidal against both Zika virus (ZIKV) (D=L) and dengue viruses (DENV). Yodha peptide efficiently inhibited DENV1 (IC50 25 uM), DENV2 (IC50 2 uM), DENV3 (IC50 70 uM), and DENV4 (IC50 30 uM).

Evidence 3 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Vero cells

Target

Target Cell Vero cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The amphibian peptide Yodha is virucidal for Zika and dengue viruses | Sci Rep | 2021

Evidence 4 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Human embryonic kidney HEK293T cells

Target

Target Cell Human embryonic kidney HEK293T cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The amphibian peptide Yodha is virucidal for Zika and dengue viruses | Sci Rep | 2021

Evidence 5 Activity

Activity

Detail Source Activity Toxicity

Toxicity Type Cytotoxic

Toxicity Raw

NA | target cell: Madin-Darby canine kidney cells

Target

Target Cell Madin-Darby canine kidney cells

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The amphibian peptide Yodha is virucidal for Zika and dengue viruses | Sci Rep | 2021

Evidence 6 Activity

Activity

Activity Endpoint 0% Hemolysis

Detail Source Activity Toxicity

Activity Measurement 1000 µM

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

0% Hemolysis | 1000 | µM | target cell: Human erythrocytes

Target

Target Cell Human erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

The amphibian peptide Yodha is virucidal for Zika and dengue viruses | Sci Rep | 2021