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Peptide record

TPDB25691

Antibacterial Antifungal Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB25691
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia ToxinPred 3.0
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and ToxinPred 3.0, with an available 3D structural model.
Sequence
SLWENFKNAGKKFILNILDKIRCRVAGGCRT
Physicochemical Analysis
C158H260N48O41S2
QHMPY
K
3552.22
10.54
7
2
12
+5
3.73
-0.223
91.29
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5625
158.35
7
Residue Composition
number
2
A
3
R
3
N
1
D
2
C
1
E
0
Q
3
G
0
H
3
I
3
L
4
K
0
M
2
F
0
P
1
S
1
T
1
W
0
Y
1
V
Amino Acid Distribution
A: 2 R: 3 N: 3 D: 1 C: 2 E: 1 Q: 0 G: 3 H: 0 I: 3 L: 3 K: 4 M: 0 F: 2 P: 0 S: 1 T: 1 W: 1 Y: 0 V: 1
Chemical Descriptors
31
C158H260N48O41S2
3552.22
10.54
+5
3.73
-0.223
Evidence Records 15 records
Evidence 1 Activity

Activity

MIC
Antibacterial
32 µM

Target

Staphylococcus aureus ATCC 6538 or MRSA NCTC 1249

Source & Reference

NA

Other

Activity tested against Gram-positive bacteria S. aureus ATCC 6538 or MRSA NCTC 1249 (MIC 32 uM), E. faecium NCTC 12697 (MIC 16 uM), Gram-negative bacteria E. coli ATCC 8739 (MIC 8 uM),
Evidence 2 Activity

Activity

MIC
Antibacterial
16 µM

Target

E. faecium NCTC 12697

Source & Reference

NA

Other

tested against Gram-positive bacteria S. aureus ATCC 6538 or MRSA NCTC 1249 (MIC 32 uM), E. faecium NCTC 12697 (MIC 16 uM), Gram-negative bacteria E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 8 uM)
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

Escherichia coli ATCC 8739

Source & Reference

NA

Other

or MRSA NCTC 1249 (MIC 32 uM), E. faecium NCTC 12697 (MIC 16 uM), Gram-negative bacteria E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), A. baumannii A
Evidence 4 Activity

Activity

MIC
Antibacterial
8 µM

Target

Klebsiella pneumoniae ATCC 43816

Source & Reference

NA

Other

, E. faecium NCTC 12697 (MIC 16 uM), Gram-negative bacteria E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), A. baumannii ATCC BAA 747 (MIC 32 uM), and yeast, C
Evidence 5 Activity

Activity

MIC
Antibacterial
16 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

NA

Other

Gram-negative bacteria E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), A. baumannii ATCC BAA 747 (MIC 32 uM), and yeast, C.albicans ATCC 10231 (MIC >128 uM).
Evidence 6 Activity

Activity

MIC
Antibacterial
32 µM

Target

A. baumannii ATCC BAA 747

Source & Reference

NA

Other

739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), A. baumannii ATCC BAA 747 (MIC 32 uM), and yeast, C.albicans ATCC 10231 (MIC >128 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
>128 µM

Target

C.albicans ATCC 10231

Source & Reference

NA

Other

), P. aeruginosa ATCC 9027 (MIC 16 uM), A. baumannii ATCC BAA 747 (MIC 32 uM), and yeast, C.albicans ATCC 10231 (MIC >128 uM).
Evidence 8 Activity

Activity

MIC
Antifungal
32 µM

Target

Staphylococcus aureus ATCC 6538 or MRSA NCTC 1249

Source & Reference

NA

Other

Activity tested against Gram-positive bacteria S. aureus ATCC 6538 or MRSA NCTC 1249 (MIC 32 uM), E. faecium NCTC 12697 (MIC 16 uM), Gram-negative bacteria E. coli ATCC 8739 (MIC 8 uM),
Evidence 9 Activity

Activity

MIC
Antifungal
16 µM

Target

E. faecium NCTC 12697

Source & Reference

NA

Other

tested against Gram-positive bacteria S. aureus ATCC 6538 or MRSA NCTC 1249 (MIC 32 uM), E. faecium NCTC 12697 (MIC 16 uM), Gram-negative bacteria E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 8 uM)
Evidence 10 Activity

Activity

MIC
Antifungal
8 µM

Target

Escherichia coli ATCC 8739

Source & Reference

NA

Other

or MRSA NCTC 1249 (MIC 32 uM), E. faecium NCTC 12697 (MIC 16 uM), Gram-negative bacteria E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), A. baumannii A
Evidence 11 Activity

Activity

MIC
Antifungal
8 µM

Target

Klebsiella pneumoniae ATCC 43816

Source & Reference

NA

Other

, E. faecium NCTC 12697 (MIC 16 uM), Gram-negative bacteria E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), A. baumannii ATCC BAA 747 (MIC 32 uM), and yeast, C
Evidence 12 Activity

Activity

MIC
Antifungal
16 µM

Target

Pseudomonas aeruginosa ATCC 9027

Source & Reference

NA

Other

Gram-negative bacteria E. coli ATCC 8739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), A. baumannii ATCC BAA 747 (MIC 32 uM), and yeast, C.albicans ATCC 10231 (MIC >128 uM).
Evidence 13 Activity

Activity

MIC
Antifungal
32 µM

Target

A. baumannii ATCC BAA 747

Source & Reference

NA

Other

739 (MIC 8 uM), K. pneumoniae ATCC 43816 (MIC 8 uM), P. aeruginosa ATCC 9027 (MIC 16 uM), A. baumannii ATCC BAA 747 (MIC 32 uM), and yeast, C.albicans ATCC 10231 (MIC >128 uM).
Evidence 14 Activity

Activity

MIC
Antifungal
>128 µM

Target

C.albicans ATCC 10231

Source & Reference

NA

Other

), P. aeruginosa ATCC 9027 (MIC 16 uM), A. baumannii ATCC BAA 747 (MIC 32 uM), and yeast, C.albicans ATCC 10231 (MIC >128 uM).
Evidence 15 Activity

Activity

50% Hemolysis
Toxicity
102.4 µM
Hemolytic Cytotoxic
50% Hemolysis | 102.4 | µM | target cell: Horse erythrocytes

Target

Horse erythrocytes

Source & Reference

NA
DBAASP
Exploring the active core of a novel antimicrobial peptide, palustrin-2LTb, from the Kuatun frog, Hylarana latouchii, using a bioinformatics-directed approach | Comput Struct Biotechnol J | 2022