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Peptide record

TPDB25669

Antibacterial Antifungal standard

21 amino acids

3D PDB MODEL

Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.

TPDB ID TPDB25669

Activity

Antibacterial Antifungal

Activity_category_statistics

Anti-infective peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 21-aa standard natural multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

SLGSSPYNDILGYPALIVIYP

FASTA

>TPDB25669|Antibacterial;Antifungal|length=21
SLGSSPYNDILGYPALIVIYP

Formula C107H162N22O31

Absent Amino Acids RCEQHKMFTW

Common Amino Acids ILPSY

Mass 2252.59

PI 3.10

Basic Residues 0

Acidic Residues 1

Hydrophobic Residues 11

Net Charge -1

Boman Index -2.12

Hydrophobicity 0.571

Aliphatic Index 130.00

Half Life

Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour

Extinction Coefficient Cystines 4470

Absorbance 280nm 198.44

Polar Residues 7

number

Amino Acid Distribution

A: 1 R: 0 N: 1 D: 1 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 3 L: 3 K: 0 M: 0 F: 0 P: 3 S: 3 T: 0 W: 0 Y: 3 V: 1

Length

Formula

C107H162N22O31

Mass

2252.59

3.10

Net Charge

-1

Boman Index

-2.12

Hydrophobicity

0.571

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2-4 µM

Target

Target Organism r. Sterne or deltaLF

Source & Reference

Database Source NA

Other

Evidence Text

active against B. anthracis str. Sterne or deltaLF (MIC 2-4 uM), B. halodurans (MIC 4 uM), B. cereus ATCC 4342 or 13472 (MIC 4-7 uM), Bacillus sp. Al Hak

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µM

Target

Target Organism B. halodurans

Source & Reference

Database Source NA

Other

Evidence Text

active against B. anthracis str. Sterne or deltaLF (MIC 2-4 uM), B. halodurans (MIC 4 uM), B. cereus ATCC 4342 or 13472 (MIC 4-7 uM), Bacillus sp. Al Hakam (MIC 7 uM), B. subtilis

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4-7 µM

Target

Target Organism B. cereus ATCC 4342 or 13472

Source & Reference

Database Source NA

Other

Evidence Text

ctive against B. anthracis str. Sterne or deltaLF (MIC 2-4 uM), B. halodurans (MIC 4 uM), B. cereus ATCC 4342 or 13472 (MIC 4-7 uM), Bacillus sp. Al Hakam (MIC 7 uM), B. subtilis (MIC 29 uM), L. monocytogenes (MIC 14 uM),

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 7 µM

Target

Target Organism p. Al Hakam

Source & Reference

Database Source NA

Other

Evidence Text

C 2-4 uM), B. halodurans (MIC 4 uM), B. cereus ATCC 4342 or 13472 (MIC 4-7 uM), Bacillus sp. Al Hakam (MIC 7 uM), B. subtilis (MIC 29 uM), L. monocytogenes (MIC 14 uM), E. faecalis (MIC 29 uM), S. aureu

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 29 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source NA

Other

Evidence Text

(MIC 4 uM), B. cereus ATCC 4342 or 13472 (MIC 4-7 uM), Bacillus sp. Al Hakam (MIC 7 uM), B. subtilis (MIC 29 uM), L. monocytogenes (MIC 14 uM), E. faecalis (MIC 29 uM), S. aureus (MIC 57 uM), not M.smeg

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 14 µM

Target

Target Organism L. monocytogenes

Source & Reference

Database Source NA

Other

Evidence Text

CC 4342 or 13472 (MIC 4-7 uM), Bacillus sp. Al Hakam (MIC 7 uM), B. subtilis (MIC 29 uM), L. monocytogenes (MIC 14 uM), E. faecalis (MIC 29 uM), S. aureus (MIC 57 uM), not M.smegmatis (MIC >128 ug/ml), E.coli

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 29 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source NA

Other

Evidence Text

Bacillus sp. Al Hakam (MIC 7 uM), B. subtilis (MIC 29 uM), L. monocytogenes (MIC 14 uM), E. faecalis (MIC 29 uM), S. aureus (MIC 57 uM), not M.smegmatis (MIC >128 ug/ml), E.coli (MIC >128 ug/ml), P.puti

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 57 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

IC 7 uM), B. subtilis (MIC 29 uM), L. monocytogenes (MIC 14 uM), E. faecalis (MIC 29 uM), S. aureus (MIC 57 uM), not M.smegmatis (MIC >128 ug/ml), E.coli (MIC >128 ug/ml), P.putida (MIC >128 ug/ml), S.

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism M.smegmatis

Source & Reference

Database Source NA

Other

Evidence Text

29 uM), L. monocytogenes (MIC 14 uM), E. faecalis (MIC 29 uM), S. aureus (MIC 57 uM), not M.smegmatis (MIC >128 ug/ml), E.coli (MIC >128 ug/ml), P.putida (MIC >128 ug/ml), S.cerevisiae (MIC >128 ug/ml), T.sti

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source NA

Other

Evidence Text

14 uM), E. faecalis (MIC 29 uM), S. aureus (MIC 57 uM), not M.smegmatis (MIC >128 ug/ml), E.coli (MIC >128 ug/ml), P.putida (MIC >128 ug/ml), S.cerevisiae (MIC >128 ug/ml), T.stipitatus (MIC >128 ug/ml),

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism P.putida

Source & Reference

Database Source NA

Other

Evidence Text

29 uM), S. aureus (MIC 57 uM), not M.smegmatis (MIC >128 ug/ml), E.coli (MIC >128 ug/ml), P.putida (MIC >128 ug/ml), S.cerevisiae (MIC >128 ug/ml), T.stipitatus (MIC >128 ug/ml), A.niger (MIC > 128 ug/ml),

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism S.cerevisiae

Source & Reference

Database Source NA

Other

Evidence Text

M), not M.smegmatis (MIC >128 ug/ml), E.coli (MIC >128 ug/ml), P.putida (MIC >128 ug/ml), S.cerevisiae (MIC >128 ug/ml), T.stipitatus (MIC >128 ug/ml), A.niger (MIC > 128 ug/ml), and T.longibrachiatum (MIC > 1

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement >128 µg/mL

Target

Target Organism T.stipitatus

Source & Reference

Database Source NA

Other

Evidence Text

g/ml), E.coli (MIC >128 ug/ml), P.putida (MIC >128 ug/ml), S.cerevisiae (MIC >128 ug/ml), T.stipitatus (MIC >128 ug/ml), A.niger (MIC > 128 ug/ml), and T.longibrachiatum (MIC > 128 ug/ml).

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2-4 µM

Target

Target Organism r. Sterne or deltaLF

Source & Reference

Database Source NA

Other

Evidence Text

active against B. anthracis str. Sterne or deltaLF (MIC 2-4 uM), B. halodurans (MIC 4 uM), B. cereus ATCC 4342 or 13472 (MIC 4-7 uM), Bacillus sp. Al Hak

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4 µM

Target

Target Organism B. halodurans

Source & Reference

Database Source NA

Other

Evidence Text

active against B. anthracis str. Sterne or deltaLF (MIC 2-4 uM), B. halodurans (MIC 4 uM), B. cereus ATCC 4342 or 13472 (MIC 4-7 uM), Bacillus sp. Al Hakam (MIC 7 uM), B. subtilis

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4-7 µM

Target

Target Organism B. cereus ATCC 4342 or 13472

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 7 µM

Target

Target Organism p. Al Hakam

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 29 µM

Target

Target Organism B. subtilis

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 14 µM

Target

Target Organism L. monocytogenes

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 29 µM

Target

Target Organism Enterococcus faecalis

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 57 µM

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >128 µg/mL

Target

Target Organism M.smegmatis

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >128 µg/mL

Target

Target Organism E.coli

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >128 µg/mL

Target

Target Organism P.putida

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >128 µg/mL

Target

Target Organism S.cerevisiae

Source & Reference

Database Source NA

Other

Evidence Text

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement >128 µg/mL

Target

Target Organism T.stipitatus

Source & Reference

Database Source NA

Other

Evidence Text

g/ml), E.coli (MIC >128 ug/ml), P.putida (MIC >128 ug/ml), S.cerevisiae (MIC >128 ug/ml), T.stipitatus (MIC >128 ug/ml), A.niger (MIC > 128 ug/ml), and T.longibrachiatum (MIC > 128 ug/ml).