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Peptide record

TPDB25660

Antibacterial Antifungal standard
121 amino acids
Basic Information
3D PDB MODEL
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TPDB25660
Antibacterial Antifungal
Anti-infective peptides
Peptipedia Antifungipept
standard
No
A 121-aa standard-residue multi-activity (Antibacterial and Antifungal) peptide sequence curated from Peptipedia and Antifungipept, with an available 3D structural model.
Sequence
SLFELGKMILQETGKNPAKSYGAYGCNCGVLGRGKPKDATDRCCYVHKCCYKAAAAAAAAADRYSYSWKDKTIVCGENNPCLKELCECDKAVAICLRENLGTYNKKYRYHLKPFCKKAAAA
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C580H918N164O168S13
A
13293.45
8.82
23
11
47
+10
1.53
-0.401
63.14
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
19660
1.48
36
Residue Composition
number
18
A
5
R
6
N
5
D
12
C
6
E
1
Q
9
G
2
H
3
I
9
L
16
K
1
M
2
F
4
P
4
S
4
T
1
W
9
Y
4
V
Amino Acid Distribution
A: 18 R: 5 N: 6 D: 5 C: 12 E: 6 Q: 1 G: 9 H: 2 I: 3 L: 9 K: 16 M: 1 F: 2 P: 4 S: 4 T: 4 W: 1 Y: 9 V: 4
Chemical Descriptors
121 reviewed residue count
C580H918N164O168S13 sequence-only estimate (linear, free termini)
13293.45 sequence-only estimate (linear, free termini)
8.82 sequence-only estimate (linear, free termini)
+10 sequence-only estimate (linear, free termini)
1.53 sequence-only estimate (linear, free termini)
-0.401 sequence-only estimate (linear, free termini)
Evidence Records 2 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Active against E.coli ATCC 25922 (20-30% inhibition at 25-100 ug/ml), S.aureus ATCC 29213 (20-30% inhibition 25-100 ug/ml), K. pneumoniae ATCC 13883 (30% inhibition at 100 ug/ml), and P. aeruginosa ATCC 28853 (~60% inhibition at 100 ug/ml). Updated 7/2021
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

Active against E.coli ATCC 25922 (20-30% inhibition at 25-100 ug/ml), S.aureus ATCC 29213 (20-30% inhibition 25-100 ug/ml), K. pneumoniae ATCC 13883 (30% inhibition at 100 ug/ml), and P. aeruginosa ATCC 28853 (~60% inhibition at 100 ug/ml). Updated 7/2021