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Peptide record

TPDB25648

Antibacterial Anticancer Toxicity standard
17 amino acids
Basic Information
3D PDB MODEL
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TPDB25648
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia ToxinPred 3.0
standard
No
A 17-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia and ToxinPred 3.0, with an available 3D structural model.
Sequence
SKKSKPGDGIRGKGVRG
Physicochemical Analysis
C72H131N27O22
ANCEQHLMFTWY
G
1727.00
11.63
6
1
2
+5
7.33
-1.447
40.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
0
0.00
2
Residue Composition
number
0
A
2
R
0
N
1
D
0
C
0
E
0
Q
5
G
0
H
1
I
0
L
4
K
0
M
0
F
1
P
2
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 1 C: 0 E: 0 Q: 0 G: 5 H: 0 I: 1 L: 0 K: 4 M: 0 F: 0 P: 1 S: 2 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
17
C72H131N27O22
1727.00
11.63
+5
7.33
-1.447
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.125-0.25 µg/mL

Target

M. smegmatis

Source & Reference

NA

Other

Alboverticillin and triculamin have the same activity spectra. Active against M. smegmatis (MIC 0.125-0.25 ug/ml), M. phlei (MIC 0.03-0.06 ug/ml), B-cereus (MIC >32 uM), E-faecium (MIC >32 uM), S-aureus
Evidence 2 Activity

Activity

MIC
Antibacterial
0.03-0.06 µg/mL

Target

M. phlei

Source & Reference

NA

Other

lamin have the same activity spectra. Active against M. smegmatis (MIC 0.125-0.25 ug/ml), M. phlei (MIC 0.03-0.06 ug/ml), B-cereus (MIC >32 uM), E-faecium (MIC >32 uM), S-aureus (MIC >32 uM), K-oxytoca (MIC >32
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human skin fibroblasts

Target

Human skin fibroblasts

Source & Reference

NA
DBAASP
Triculamin: An Unusual Lasso Peptide with Potent Antimycobacterial Activity. | J Nat Prod | 2022