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Peptide record

TPDB25625

Antibacterial Anticancer Hemolysis Toxicity standard
37 amino acids
Basic Information
3D PDB MODEL
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TPDB25625
Antibacterial Anticancer Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CancerPPD 2.0 dbACP Hemolytic2
standard
No
A 37-aa standard natural multi-activity (Antibacterial, Anticancer, Hemolysis, and other sources) peptide sequence curated from Peptipedia, CancerPPD 2.0, dbACP, and other sources, with an available 3D structural model.
Sequence
SILSLFKMGAKALGKTLIKQAGKAGAEYVACKATNQC
Physicochemical Analysis
C168H286N46O48S3
RDHPW
A
3814.58
10.12
6
1
17
+5
3.36
0.200
90.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
1615
42.34
10
Residue Composition
number
7
A
0
R
1
N
0
D
2
C
1
E
2
Q
4
G
0
H
2
I
4
L
6
K
1
M
1
F
0
P
2
S
2
T
0
W
1
Y
1
V
Amino Acid Distribution
A: 7 R: 0 N: 1 D: 0 C: 2 E: 1 Q: 2 G: 4 H: 0 I: 2 L: 4 K: 6 M: 1 F: 1 P: 0 S: 2 T: 2 W: 0 Y: 1 V: 1
Chemical Descriptors
37
C168H286N46O48S3
3814.58
10.12
+5
3.36
0.200
Evidence Records 14 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.5-3 µM

Target

Staphylococcus aureus MTCC 9542 or MRSA ATCC 43300

Source & Reference

NA

Other

C-terminal amidated form: active against Gram+ S. aureus MTCC 9542 or MRSA ATCC 43300 (MIC 1.5-3 uM), B. subtilis MTCC 14416 (MIC 15 uM), B. coagulans ATCC 7050 (MIC 10 uM), VRE ATCC 29212 (
Evidence 2 Activity

Activity

MIC
Antibacterial
15 µM

Target

B. subtilis MTCC 14416

Source & Reference

NA

Other

midated form: active against Gram+ S. aureus MTCC 9542 or MRSA ATCC 43300 (MIC 1.5-3 uM), B. subtilis MTCC 14416 (MIC 15 uM), B. coagulans ATCC 7050 (MIC 10 uM), VRE ATCC 29212 (MIC 12 uM), S. mutans MTCC 497 (MIC
Evidence 3 Activity

Activity

MIC
Antibacterial
10 µM

Target

B. coagulans ATCC 7050

Source & Reference

NA

Other

. aureus MTCC 9542 or MRSA ATCC 43300 (MIC 1.5-3 uM), B. subtilis MTCC 14416 (MIC 15 uM), B. coagulans ATCC 7050 (MIC 10 uM), VRE ATCC 29212 (MIC 12 uM), S. mutans MTCC 497 (MIC 5 uM), S. gordonnii MTCC 2695 (MIC 5
Evidence 4 Activity

Activity

MIC
Antibacterial
5 µM

Target

S. mutans MTCC 497

Source & Reference

NA

Other

s MTCC 14416 (MIC 15 uM), B. coagulans ATCC 7050 (MIC 10 uM), VRE ATCC 29212 (MIC 12 uM), S. mutans MTCC 497 (MIC 5 uM), S. gordonnii MTCC 2695 (MIC 5 uM), Gram- V. cholerae MCV09 (MIC 7 uM), E. coli ATCC 2592
Evidence 5 Activity

Activity

MIC
Antibacterial
5 µM

Target

S. gordonnii MTCC 2695

Source & Reference

NA

Other

agulans ATCC 7050 (MIC 10 uM), VRE ATCC 29212 (MIC 12 uM), S. mutans MTCC 497 (MIC 5 uM), S. gordonnii MTCC 2695 (MIC 5 uM), Gram- V. cholerae MCV09 (MIC 7 uM), E. coli ATCC 25922 (MIC 10 uM), fish pathogens A. hy
Evidence 6 Activity

Activity

MIC
Antibacterial
7 µM

Target

V. cholerae MCV09

Source & Reference

NA

Other

9212 (MIC 12 uM), S. mutans MTCC 497 (MIC 5 uM), S. gordonnii MTCC 2695 (MIC 5 uM), Gram- V. cholerae MCV09 (MIC 7 uM), E. coli ATCC 25922 (MIC 10 uM), fish pathogens A. hydrophilia (MIC 20 uM), A. sobria (MI
Evidence 7 Activity

Activity

MIC
Antibacterial
10 µM

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

CC 497 (MIC 5 uM), S. gordonnii MTCC 2695 (MIC 5 uM), Gram- V. cholerae MCV09 (MIC 7 uM), E. coli ATCC 25922 (MIC 10 uM), fish pathogens A. hydrophilia (MIC 20 uM), A. sobria (MIC 3 uM). Toxic to cancer cells H
Evidence 8 Activity

Activity

MIC
Antibacterial
20 µM

Target

A. hydrophilia

Source & Reference

NA

Other

5 uM), Gram- V. cholerae MCV09 (MIC 7 uM), E. coli ATCC 25922 (MIC 10 uM), fish pathogens A. hydrophilia (MIC 20 uM), A. sobria (MIC 3 uM). Toxic to cancer cells Hep3B.
Evidence 9 Activity

Activity

MIC
Antibacterial
3 µM

Target

A. sobria

Source & Reference

NA

Other

09 (MIC 7 uM), E. coli ATCC 25922 (MIC 10 uM), fish pathogens A. hydrophilia (MIC 20 uM), A. sobria (MIC 3 uM). Toxic to cancer cells Hep3B.
Evidence 10 Activity

Activity

72% Cytotoxicity
Toxicity
25 µM
Cytotoxic
72% Cytotoxicity | 25 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Identification and functional characterisation of Esculentin-2 HYba peptides and their C-terminally amidated analogs from the skin secretion of an endemic frog. | Nat Prod Res | 2021
Evidence 11 Activity

Activity

50% Hemolysis
Toxicity
10 µM
Hemolytic Cytotoxic
50% Hemolysis | 10 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional characterisation of Esculentin-2 HYba peptides and their C-terminally amidated analogs from the skin secretion of an endemic frog. | Nat Prod Res | 2021
Evidence 12 Activity

Activity

50% Hemolysis
Toxicity
12 µM
Hemolytic Cytotoxic
50% Hemolysis | 12 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Identification and functional characterisation of Esculentin-2 HYba peptides and their C-terminally amidated analogs from the skin secretion of an endemic frog. | Nat Prod Res | 2021
Evidence 13 Activity

Activity

75% Cytotoxicity
Toxicity
25 µM
Cytotoxic
75% Cytotoxicity | 25 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Identification and functional characterisation of Esculentin-2 HYba peptides and their C-terminally amidated analogs from the skin secretion of an endemic frog. | Nat Prod Res | 2021
Evidence 14 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Nat Prod Res. 2021 Apr 35(8):1262-1266.