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Peptide record

TPDB25605

Antibacterial Antifungal Toxicity standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB25605
Antibacterial Antifungal Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb
standard
No
A 11-aa standard-residue multi-activity (Antibacterial, Antifungal, and Toxicity) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.
Sequence
SHHRCRRSHRC
Physicochemical Analysis

Sequence-only estimates for a linear peptide with free termini, not experimentally measured molecular properties. Mass and formula exclude cyclization and disulfide formation. The optical estimates assume paired cysteines, 280 nm, 1 g/L and a 1 cm path. The N-end rule estimate is not a measured plasma half-life.

C54H91N29O14S2
ANDEQGILKMFPTWYV
R
1434.62
11.93
7
0
0
+4
7.08
-2.200
0.00
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
125
0.09
4
Residue Composition
number
0
A
4
R
0
N
0
D
2
C
0
E
0
Q
0
G
3
H
0
I
0
L
0
K
0
M
0
F
0
P
2
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 2 E: 0 Q: 0 G: 0 H: 3 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 2 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11 reviewed residue count
C54H91N29O14S2 sequence-only estimate (linear, free termini)
1434.62 sequence-only estimate (linear, free termini)
11.93 sequence-only estimate (linear, free termini)
+4 sequence-only estimate (linear, free termini)
7.08 sequence-only estimate (linear, free termini)
-2.200 sequence-only estimate (linear, free termini)
Evidence Records 1 records
Evidence 1 Activity

Activity

50% Cytotoxicity
Toxicity
>32 µg/mL
Cytotoxic
50% Cytotoxicity | >32 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Cationic Intrinsically Disordered Antimicrobial Peptides (CIDAMPs) Represent a New Paradigm of Innate Defense with a Potential for Novel Anti-Infectives. | Sci Rep | 2019