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Peptide record

TPDB25566

Antibacterial Antifungal Antiviral Hemolysis Toxicity standard
24 amino acids
Basic Information
3D PDB MODEL
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TPDB25566
Antibacterial Antifungal Antiviral Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia AFP-GFuse DRAVP 2.0 Hemolytic2
standard
No
A 24-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from Peptipedia, AFP-GFuse, DRAVP 2.0, and other sources, with an available 3D structural model.
Sequence
SDSVVSDIICTTFCSVTWCQSNCC
Physicochemical Analysis
C106H165N27O39S5
AREGHLKMPY
CS
2601.93
2.92
0
2
7
-2
-0.06
0.663
68.75
Mammalian: 1.9 hour Yeast: >20 hour E.coli: >10 hour
5750
220.99
15
Residue Composition
number
0
A
0
R
1
N
2
D
5
C
0
E
1
Q
0
G
0
H
2
I
0
L
0
K
0
M
1
F
0
P
5
S
3
T
1
W
0
Y
3
V
Amino Acid Distribution
A: 0 R: 0 N: 1 D: 2 C: 5 E: 0 Q: 1 G: 0 H: 0 I: 2 L: 0 K: 0 M: 0 F: 1 P: 0 S: 5 T: 3 W: 1 Y: 0 V: 3
Chemical Descriptors
24
C106H165N27O39S5
2601.93
2.92
-2
-0.06
0.663
Evidence Records 12 records
Evidence 1 Activity

Activity

MIC
Antibacterial
0.8 µg/mL

Target

Staphylococcus aureus MTCC 1430

Source & Reference

NA

Other

killed S. aureus MTCC 1430 (MIC 0.8 ug/ml), E. coli MTCC 1610 (MIC 1.2 ug/ml), and C. albicans MTCC 183 (MIC 30-45 ug/ml) in 30 min
Evidence 2 Activity

Activity

MIC
Antibacterial
1.2 µg/mL

Target

Escherichia coli MTCC 1610

Source & Reference

NA

Other

killed S. aureus MTCC 1430 (MIC 0.8 ug/ml), E. coli MTCC 1610 (MIC 1.2 ug/ml), and C. albicans MTCC 183 (MIC 30-45 ug/ml) in 30 min at 4 ug/ml, 6 ug/ml and 20 ug/ml, r
Evidence 3 Activity

Activity

MIC
Antibacterial
30-45 µg/mL

Target

Candida albicans MTCC 183

Source & Reference

NA

Other

killed S. aureus MTCC 1430 (MIC 0.8 ug/ml), E. coli MTCC 1610 (MIC 1.2 ug/ml), and C. albicans MTCC 183 (MIC 30-45 ug/ml) in 30 min at 4 ug/ml, 6 ug/ml and 20 ug/ml, respectively. It inhibited ~99% viral growth
Evidence 4 Activity

Activity

MIC
Antifungal
0.8 µg/mL

Target

Staphylococcus aureus MTCC 1430

Source & Reference

NA

Other

killed S. aureus MTCC 1430 (MIC 0.8 ug/ml), E. coli MTCC 1610 (MIC 1.2 ug/ml), and C. albicans MTCC 183 (MIC 30-45 ug/ml) in 30 min
Evidence 5 Activity

Activity

MIC
Antifungal
1.2 µg/mL

Target

Escherichia coli MTCC 1610

Source & Reference

NA

Other

killed S. aureus MTCC 1430 (MIC 0.8 ug/ml), E. coli MTCC 1610 (MIC 1.2 ug/ml), and C. albicans MTCC 183 (MIC 30-45 ug/ml) in 30 min at 4 ug/ml, 6 ug/ml and 20 ug/ml, r
Evidence 6 Activity

Activity

MIC
Antifungal
30-45 µg/mL

Target

Candida albicans MTCC 183

Source & Reference

NA

Other

killed S. aureus MTCC 1430 (MIC 0.8 ug/ml), E. coli MTCC 1610 (MIC 1.2 ug/ml), and C. albicans MTCC 183 (MIC 30-45 ug/ml) in 30 min at 4 ug/ml, 6 ug/ml and 20 ug/ml, respectively. It inhibited ~99% viral growth
Evidence 7 Activity

Activity

MIC
Antiviral
0.8 µg/mL

Target

Staphylococcus aureus MTCC 1430

Source & Reference

DRAVP 2.0

Other

killed S. aureus MTCC 1430 (MIC 0.8 ug/ml), E. coli MTCC 1610 (MIC 1.2 ug/ml), and C. albicans MTCC 183 (MIC 30-45 ug/ml) in 30 min
Evidence 8 Activity

Activity

MIC
Antiviral
1.2 µg/mL

Target

Escherichia coli MTCC 1610

Source & Reference

DRAVP 2.0

Other

killed S. aureus MTCC 1430 (MIC 0.8 ug/ml), E. coli MTCC 1610 (MIC 1.2 ug/ml), and C. albicans MTCC 183 (MIC 30-45 ug/ml) in 30 min at 4 ug/ml, 6 ug/ml and 20 ug/ml, r
Evidence 9 Activity

Activity

MIC
Antiviral
30-45 µg/mL

Target

Candida albicans MTCC 183

Source & Reference

DRAVP 2.0

Other

killed S. aureus MTCC 1430 (MIC 0.8 ug/ml), E. coli MTCC 1610 (MIC 1.2 ug/ml), and C. albicans MTCC 183 (MIC 30-45 ug/ml) in 30 min at 4 ug/ml, 6 ug/ml and 20 ug/ml, respectively. It inhibited ~99% viral growth
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
6 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 6 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Brevicillin, a novel lanthipeptide from the genus Brevibacillus with antimicrobial, antifungal, and antiviral activity. | J Appl Microbiol | 2023
Evidence 11 Activity

Activity

50% Cell death
Toxicity
25 µg/mL
Cytotoxic
50% Cell death | 25 | µg/mL | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
Brevicillin, a novel lanthipeptide from the genus Brevibacillus with antimicrobial, antifungal, and antiviral activity. | J Appl Microbiol | 2023
Evidence 12 Activity

Activity

50% Cell death
Toxicity
25 µg/mL
Cytotoxic
50% Cell death | 25 | µg/mL | target cell: Vero E6 cells

Target

Vero E6 cells

Source & Reference

NA
DBAASP
Brevicillin, a novel lanthipeptide from the genus Brevibacillus with antimicrobial, antifungal, and antiviral activity. | J Appl Microbiol | 2023