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Peptide record

TPDB25487

Antibacterial Toxicity modified_plain modified
5 amino acids
Basic Information
3D PDB MODEL
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TPDB25487
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 5-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
RXRXR
Physicochemical Analysis
C18H38N12O4
ANDCEQGHILKMFPSTWYV
R
486.58
12.70
3
0
0
+3
2.43
-2.700
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C18H38N12O4
486.58
12.70
+3
2.43
-2.700
Evidence Records 8 records
Evidence 1 Activity

Activity

1% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
1% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and Antibiofilm Activity of UP-5, an Ultrashort Antimicrobial Peptide Designed Using Only Arginine and Biphenylalanine. | Pharmaceuticals (Basel) | 2018
Evidence 2 Activity

Activity

2% Hemolysis
Toxicity
125 µM
Hemolytic Cytotoxic
2% Hemolysis | 125 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and Antibiofilm Activity of UP-5, an Ultrashort Antimicrobial Peptide Designed Using Only Arginine and Biphenylalanine. | Pharmaceuticals (Basel) | 2018
Evidence 3 Activity

Activity

3% Hemolysis
Toxicity
150-200 µM
Hemolytic Cytotoxic
3% Hemolysis | 150-200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial and Antibiofilm Activity of UP-5, an Ultrashort Antimicrobial Peptide Designed Using Only Arginine and Biphenylalanine. | Pharmaceuticals (Basel) | 2018
Evidence 4 Activity

Activity

IC50
Toxicity
275 µM
Cytotoxic
IC50 | 275 | µM | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Antimicrobial and Antibiofilm Activity of UP-5, an Ultrashort Antimicrobial Peptide Designed Using Only Arginine and Biphenylalanine. | Pharmaceuticals (Basel) | 2018
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
>1000 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >1000 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Design and synthesis of oligo-lipidated arginyl peptide (OLAP) dimers with enhanced physicochemical activity, peptide stability and their antimicrobial actions against MRSA infections. | Amino Acids | 2018
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
271.4±21.2 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 271.4±21.2 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Design and synthesis of oligo-lipidated arginyl peptide (OLAP) dimers with enhanced physicochemical activity, peptide stability and their antimicrobial actions against MRSA infections | Amino Acids | 2018
Evidence 7 Activity

Activity

50% hemolysis
Toxicity
380.4±17.1 µg/mL
Hemolytic Cytotoxic
50% hemolysis | 380.4±17.1 | µg/mL | target cell: Rabbit erythrocytes

Target

Rabbit erythrocytes

Source & Reference

NA
DBAASP
Design and synthesis of oligo-lipidated arginyl peptide (OLAP) dimers with enhanced physicochemical activity, peptide stability and their antimicrobial actions against MRSA infections. | Amino Acids | 2018
Evidence 8 Activity

Activity

1% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
1% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The design and evaluation of the antimicrobial activity of a novel conjugated penta-ultrashort antimicrobial peptide in combination with conventional antibiotics against sensitive and resistant strains of S. aureus and E. coli. | Res Pharm Sci | 2022