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Peptide record

TPDB25472

Antibacterial Toxicity modified_plain modified
5 amino acids
Basic Information
3D PDB MODEL
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TPDB25472
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 5-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
RWXWR
Physicochemical Analysis
C34H46N12O5
ANDCEQGHILKMFPSTYV
RW
702.82
12.40
2
0
2
+2
-2.08
-2.160
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
1565.13
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
5
C34H46N12O5
702.82
12.40
+2
-2.08
-2.160
Evidence Records 5 records
Evidence 1 Activity

Activity

10% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
10% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial evaluation of structurally amphipathic, membrane active small cationic peptidomimetics: synthesized by incorporating 3-amino benzoic acid as peptidomimetic element. | Eur J Med Chem | 2014
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
410 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 410 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antibacterial evaluation of structurally amphipathic, membrane active small cationic peptidomimetics: synthesized by incorporating 3-amino benzoic acid as peptidomimetic element. | Eur J Med Chem | 2014
Evidence 3 Activity

Activity

5% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 125 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Novel Miniature Membrane Active Lipopeptidomimetics against Planktonic and Biofilm Embedded Methicillin-Resistant Staphylococcus aureus | Sci Rep | 2018
Evidence 4 Activity

Activity

33% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
33% Hemolysis | 250 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
Novel Miniature Membrane Active Lipopeptidomimetics against Planktonic and Biofilm Embedded Methicillin-Resistant Staphylococcus aureus | Sci Rep | 2018
Evidence 5 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Novel Miniature Membrane Active Lipopeptidomimetics against Planktonic and Biofilm Embedded Methicillin-Resistant Staphylococcus aureus | Sci Rep | 2018