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Peptide record

TPDB25471

Antibacterial Anticancer Toxicity modified_plain modified
21 amino acids
Basic Information
3D PDB MODEL
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TPDB25471
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 21-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
RWXVYAYVRVRGVLVRYRRXW
Physicochemical Analysis
C121H185N39O23
NDCEQHIKMFPST
R
2554.05
12.11
6
0
12
+6
-2.03
-0.310
92.38
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
15470
605.71
3
Residue Composition
number
1
A
6
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
3
Y
5
V
Amino Acid Distribution
A: 1 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 3 V: 5
Chemical Descriptors
21
C121H185N39O23
2554.05
12.11
+6
-2.03
-0.310
Evidence Records 5 records
Evidence 1 Activity

Activity

15% Hemolysis
Toxicity
29.9 µM
Hemolytic Cytotoxic
15% Hemolysis | 29.9 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Redesigning Arenicin-1, an Antimicrobial Peptide from the Marine Polychaeta Arenicola marina, by Strand Rearrangement or Branching, Substitution of Specific Residues, and Backbone Linearization or Cyclization. | Mar Drugs | 2019
Evidence 2 Activity

Activity

50% Hemolysis
Toxicity
>80 µM
Hemolytic Cytotoxic
50% Hemolysis | >80 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Redesigning Arenicin-1, an Antimicrobial Peptide from the Marine Polychaeta Arenicola marina, by Strand Rearrangement or Branching, Substitution of Specific Residues, and Backbone Linearization or Cyclization. | Mar Drugs | 2019
Evidence 3 Activity

Activity

50% Cytotoxicity
Toxicity
>100 µM
Cytotoxic
50% Cytotoxicity | >100 | µM | target cell: Human bronchial epithelial cells BEAS-2B

Target

Human bronchial epithelial cells BEAS-2B

Source & Reference

NA
DBAASP
Promising antibacterial efficacy of arenicin peptides against the emerging opportunistic pathogen Mycobacterium abscessus | J Biomed Sci | 2024
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>100 µM
Hemolytic Cytotoxic
50% Hemolysis | >100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Promising antibacterial efficacy of arenicin peptides against the emerging opportunistic pathogen Mycobacterium abscessus | J Biomed Sci | 2024
Evidence 5 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Mar Drugs. 2019 Jun 23 17(6):376.