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Peptide record

TPDB25460

Antibacterial Antifungal Hemolysis Toxicity standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB25460
Antibacterial Antifungal Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP PD_Hemolysis
standard
No
A 4-aa standard natural multi-activity (Antibacterial, Antifungal, Hemolysis, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
RWWR
Physicochemical Analysis
C34H46N12O5
ANDCEQGHILKMFPSTYV
RW
702.82
12.40
2
0
2
+2
-2.08
-2.700
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
1565.13
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
4
C34H46N12O5
702.82
12.40
+2
-2.08
-2.700
Evidence Records 8 records
Evidence 1 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
The pharmacophore of short cationic antibacterial peptides. | J Med Chem | 2003
Evidence 2 Activity

Activity

40% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
40% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 3 Activity

Activity

65% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
65% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 4 Activity

Activity

90% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
90% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 5 Activity

Activity

5% Hemolysis
Toxicity
62.5 µg/mL
Hemolytic Cytotoxic
5% Hemolysis | 62.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 6 Activity

Activity

18% Hemolysis
Toxicity
125 µg/mL
Hemolytic Cytotoxic
18% Hemolysis | 125 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 7 Activity

Activity

35% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
35% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the antimicrobial pharmacophore to enable discovery of short lipopeptides with multiple modes of action. | Eur J Med Chem | 2014
Evidence 8 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis