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Peptide record

TPDB25459

Antibacterial Anticancer Antifungal Toxicity standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB25459
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
standard
No
A 7-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Sequence
RWWKWWK
Physicochemical Analysis
C62H78N16O8
ANDCEQGHILMFPSTYV
W
1175.40
11.64
3
0
4
+3
-4.61
-2.271
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
1871.70
0
Residue Composition
number
0
A
1
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 1 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
7
C62H78N16O8
1175.40
11.64
+3
-4.61
-2.271
Evidence Records 3 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
<500 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | <500 | µg/mL | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Effects of Rationally Designed Physico-Chemical Variants of the Peptide PuroA on Biocidal Activity towards Bacterial and Mammalian Cells. | Int J Mol Sci | 2020
Evidence 2 Activity

Activity

IC50
Toxicity
250 µg/mL
Cytotoxic
IC50 | 250 | µg/mL | target cell: Mouse fibroblasts NIH 3T3

Target

Mouse fibroblasts NIH 3T3

Source & Reference

NA
DBAASP
Effects of Rationally Designed Physico-Chemical Variants of the Peptide PuroA on Biocidal Activity towards Bacterial and Mammalian Cells. | Int J Mol Sci | 2020
Evidence 3 Activity

Activity

IC50
Toxicity
250 µg/mL
Hemolytic Cytotoxic
Hemolytic_activity: Sheep erythrocytes: No hemolysis up tp 500 µg/ml | Cytotoxicity: NIH 3T3: IC50=250 µg/ml

Target

erythrocytes

Source & Reference

NA
DRAMP
Int J Mol Sci. 2020 Nov 16 21(22):8624.