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Peptide record

TPDB25451

Antibacterial Anticancer Toxicity modified_plain modified
7 amino acids
Basic Information
3D PDB MODEL
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TPDB25451
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 7-aa modified multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
RWRWRWX
Physicochemical Analysis
C51H68N18O7
ANDCEQGHILKMFPSTYV
RW
1045.22
12.70
3
0
3
+3
-3.12
-2.314
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
1578.62
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
7
C51H68N18O7
1045.22
12.70
+3
-3.12
-2.314
Evidence Records 7 records
Evidence 1 Activity

Activity

52% Hemolysis
Toxicity
140 µM
Hemolytic Cytotoxic
52% Hemolysis | 140 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short antibacterial peptides with significantly reduced hemolytic activity can be identified by a systematic L-to-D exchange scan of their amino acid residues. | ACS Comb Sci | 2013
Evidence 2 Activity

Activity

<10% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
<10% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the activity of a short arg-trp antimicrobial Peptide by lipidation of a C- or N-terminal lysine side-chain. | ACS Med Chem Lett | 2012
Evidence 3 Activity

Activity

>50% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
>50% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the activity of a short arg-trp antimicrobial Peptide by lipidation of a C- or N-terminal lysine side-chain. | ACS Med Chem Lett | 2012
Evidence 4 Activity

Activity

16% Hemolysis
Toxicity
142 µM
Hemolytic Cytotoxic
16% Hemolysis | 142 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short antibacterial peptides with significantly reduced hemolytic activity can be identified by a systematic L-to-D exchange scan of their amino acid residues. | ACS Comb Sci | 2013
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
285 µM
Hemolytic Cytotoxic
50% Hemolysis | 285 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the activity of a short arg-trp antimicrobial Peptide by lipidation of a C- or N-terminal lysine side-chain. | ACS Med Chem Lett | 2012
Evidence 6 Activity

Activity

IC50
Toxicity
31.3 µM
Cytotoxic
IC50 | 31.3 | µM | target cell: Human fibroblasts

Target

Human fibroblasts

Source & Reference

NA
DBAASP
Tuning the activity of a short arg-trp antimicrobial Peptide by lipidation of a C- or N-terminal lysine side-chain. | ACS Med Chem Lett | 2012
Evidence 7 Activity

Activity

IC50
Toxicity
31.3 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes:16% Hemolysis=142µM 50% Hemolysis=285µM | Cytotoxicity: Human fibroblasts: IC50=31.3µM

Target

erythrocytes

Source & Reference

NA
DRAMP
ACS Comb Sci. 2013 Nov 11 15(11):585-92.