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Peptide record

TPDB25445

[RW]3 Antibacterial Anticancer Antifungal Antiviral Cell-penetrating Peptides Toxicity standard
6 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB25445
[RW]3
Antibacterial Anticancer Antifungal Antiviral Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia AntiCP 2.0 iACP-DRLF CAFPdb DRAMP dbAMP CPPsite3.0
standard
No
A 6-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, AntiCP 2.0, iACP-DRLF, and other sources, with an available 3D structural model.
Sequence
RWRWRW
Physicochemical Analysis
C51H68N18O7
ANDCEQGHILKMFPSTYV
RW
1045.22
12.70
3
0
3
+3
-3.12
-2.700
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
16500
1578.62
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
3
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 3 Y: 0 V: 0
Chemical Descriptors
6
C51H68N18O7
1045.22
12.70
+3
-3.12
-2.700
Free
L
Cationic
Cyclic
Free
N[C@@H](CS)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)NCC(=O)N[C@@H](CC(=O)O)C(=O)O
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2 µg/mL

Target

B. subtilis 168

Source & Reference

dbAMP DRAMP

Other

Source Activity Label Source Definition
Antibacterial
DRAMP antibacterial activity supported by MIC records against bacterial target organisms. dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against B. subtilis 168 (MIC 2 ug/ml), S. aureus SG511 or Mu50 VISA or ATCC43300 MRSA (MIC 8-16 ug/ml), S. aureus COL/MRSA (MIC
Evidence 2 Activity

Activity

MIC
Antibacterial
8-16 µg/mL

Target

Staphylococcus aureus SG511 or Mu50 VISA or ATCC43300 MRSA

Source & Reference

dbAMP DRAMP

Other

Active against B. subtilis 168 (MIC 2 ug/ml), S. aureus SG511 or Mu50 VISA or ATCC43300 MRSA (MIC 8-16 ug/ml), S. aureus COL/MRSA (MIC 96 ug/ml), E. coli DSM30083 (MIC 32 ug/ml), E-coli W3110 (MIC >6
Evidence 3 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

Escherichia coli DSM30083

Source & Reference

dbAMP DRAMP

Other

SG511 or Mu50 VISA or ATCC43300 MRSA (MIC 8-16 ug/ml), S. aureus COL/MRSA (MIC 96 ug/ml), E. coli DSM30083 (MIC 32 ug/ml), E-coli W3110 (MIC >64 ug/ml) A. baumannii DSM30007 (MIC 32 ug/ml), P-aeruginosa PAO1 (MI
Evidence 4 Activity

Activity

MIC
Antibacterial
32 µg/mL

Target

A. baumannii DSM30007

Source & Reference

dbAMP DRAMP

Other

us COL/MRSA (MIC 96 ug/ml), E. coli DSM30083 (MIC 32 ug/ml), E-coli W3110 (MIC >64 ug/ml) A. baumannii DSM30007 (MIC 32 ug/ml), P-aeruginosa PAO1 (MIC >64 ug/ml) ( Wenzel et al., 2016 ).
Evidence 5 Activity

Activity

MIC
Antifungal
2 µg/mL

Target

B. subtilis 168

Source & Reference

dbAMP DRAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
DRAMP antifungal activity supported by activity records against fungal target organisms. dbAMP classified under the Anti-fungal function class.
Active against B. subtilis 168 (MIC 2 ug/ml), S. aureus SG511 or Mu50 VISA or ATCC43300 MRSA (MIC 8-16 ug/ml), S. aureus COL/MRSA (MIC
Evidence 6 Activity

Activity

MIC
Antifungal
8-16 µg/mL

Target

Staphylococcus aureus SG511 or Mu50 VISA or ATCC43300 MRSA

Source & Reference

dbAMP DRAMP CAFPdb

Other

Active against B. subtilis 168 (MIC 2 ug/ml), S. aureus SG511 or Mu50 VISA or ATCC43300 MRSA (MIC 8-16 ug/ml), S. aureus COL/MRSA (MIC 96 ug/ml), E. coli DSM30083 (MIC 32 ug/ml), E-coli W3110 (MIC >6
Evidence 7 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

Escherichia coli DSM30083

Source & Reference

dbAMP DRAMP CAFPdb

Other

SG511 or Mu50 VISA or ATCC43300 MRSA (MIC 8-16 ug/ml), S. aureus COL/MRSA (MIC 96 ug/ml), E. coli DSM30083 (MIC 32 ug/ml), E-coli W3110 (MIC >64 ug/ml) A. baumannii DSM30007 (MIC 32 ug/ml), P-aeruginosa PAO1 (MI
Evidence 8 Activity

Activity

MIC
Antifungal
32 µg/mL

Target

A. baumannii DSM30007

Source & Reference

dbAMP DRAMP CAFPdb

Other

us COL/MRSA (MIC 96 ug/ml), E. coli DSM30083 (MIC 32 ug/ml), E-coli W3110 (MIC >64 ug/ml) A. baumannii DSM30007 (MIC 32 ug/ml), P-aeruginosa PAO1 (MIC >64 ug/ml) ( Wenzel et al., 2016 ).
Evidence 9 Activity

Activity

MIC
Antiviral
2 µg/mL

Target

B. subtilis 168

Source & Reference

DRAMP

Other

Source Activity Label Source Definition
Antiviral
DRAMP antiviral activity supported by activity records against viral targets.
Active against B. subtilis 168 (MIC 2 ug/ml), S. aureus SG511 or Mu50 VISA or ATCC43300 MRSA (MIC 8-16 ug/ml), S. aureus COL/MRSA (MIC
Evidence 10 Activity

Activity

MIC
Antiviral
8-16 µg/mL

Target

Staphylococcus aureus SG511 or Mu50 VISA or ATCC43300 MRSA

Source & Reference

DRAMP

Other

Active against B. subtilis 168 (MIC 2 ug/ml), S. aureus SG511 or Mu50 VISA or ATCC43300 MRSA (MIC 8-16 ug/ml), S. aureus COL/MRSA (MIC 96 ug/ml), E. coli DSM30083 (MIC 32 ug/ml), E-coli W3110 (MIC >6
Evidence 11 Activity

Activity

MIC
Antiviral
32 µg/mL

Target

Escherichia coli DSM30083

Source & Reference

DRAMP

Other

SG511 or Mu50 VISA or ATCC43300 MRSA (MIC 8-16 ug/ml), S. aureus COL/MRSA (MIC 96 ug/ml), E. coli DSM30083 (MIC 32 ug/ml), E-coli W3110 (MIC >64 ug/ml) A. baumannii DSM30007 (MIC 32 ug/ml), P-aeruginosa PAO1 (MI
Evidence 12 Activity

Activity

MIC
Antiviral
32 µg/mL

Target

A. baumannii DSM30007

Source & Reference

DRAMP

Other

us COL/MRSA (MIC 96 ug/ml), E. coli DSM30083 (MIC 32 ug/ml), E-coli W3110 (MIC >64 ug/ml) A. baumannii DSM30007 (MIC 32 ug/ml), P-aeruginosa PAO1 (MIC >64 ug/ml) ( Wenzel et al., 2016 ).
Evidence 13 Activity

Activity

Cell-penetrating Peptides

Target

MCF-7

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Cyclic L Cationic
Synthetic
Silver nanoparticles (AgNPs)
Mitochondria
Enhance uptake of AgNP
Phagocytosis or passive nonspecific diffusion
In vitro
CCGGGSCCCSCC
Evidence 14 Activity

Activity

50% Hemolysis
Toxicity
210 µM
Hemolytic Cytotoxic
50% Hemolysis | 210 | µM | target cell: Sheep erythrocytes

Target

Sheep erythrocytes

Source & Reference

NA
DBAASP
Length effects in antimicrobial peptides of the (RW)n series | Antimicrob Agents Chemother | 2007
Evidence 15 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial activity of short arginine- and tryptophan-rich peptides. | J Pept Sci | 2002
Evidence 16 Activity

Activity

17% Hemolysis
Toxicity
333 µM
Hemolytic Cytotoxic
17% Hemolysis | 333 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Modulating the activity of short arginine-tryptophan containing antibacterial peptides with N-terminal metallocenoyl groups. | Beilstein J Org Chem | 2012
Evidence 17 Activity

Activity

<10% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
<10% Hemolysis | 250 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Tuning the activity of a short arg-trp antimicrobial Peptide by lipidation of a C- or N-terminal lysine side-chain. | ACS Med Chem Lett | 2012
Evidence 18 Activity

Activity

2% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
2% Hemolysis | 100 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cyclic antimicrobial R-, W-rich peptides: the role of peptide structure and E. coli outer and inner membranes in activity and the mode of action. | Eur Biophys J | 2011
Additional Detail Fields 1 fields
CCGGGSCCCSCC