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Peptide record

TPDB25428

Antibacterial Anticancer Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB25428
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RWLKLNGRWLKL
Physicochemical Analysis
C76H123N23O14
ADCEQHIMFPSTYV
L
1582.96
12.42
4
0
6
+4
-1.91
-0.608
130.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
694.90
1
Residue Composition
number
0
A
2
R
1
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
4
L
2
K
0
M
0
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 1 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 4 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
12
C76H123N23O14
1582.96
12.42
+4
-1.91
-0.608
Evidence Records 3 records
Evidence 1 Activity

Activity

0% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
0% Hemolysis | 256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cross-Strand Interaction, Central Bending, and Sequence Pattern Act as Biomodulators of Simplified β-Hairpin Antimicrobial Amphiphiles. | Small | 2021
Evidence 2 Activity

Activity

5% Killing
Toxicity
64 µM
Cytotoxic
5% Killing | 64 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Cross-Strand Interaction, Central Bending, and Sequence Pattern Act as Biomodulators of Simplified β-Hairpin Antimicrobial Amphiphiles. | Small | 2021
Evidence 3 Activity

Activity

5% Killing
Toxicity
64 µM
Cytotoxic
5% Killing | 64 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Cross-Strand Interaction, Central Bending, and Sequence Pattern Act as Biomodulators of Simplified β-Hairpin Antimicrobial Amphiphiles. | Small | 2021