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Peptide record

TPDB25425

Antibacterial Antifungal Antiparasitic Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
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TPDB25425
Antibacterial Antifungal Antiparasitic Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia Antifungipept dbAMP 3.0 i2APP
standard
No
A 38-aa standard natural multi-activity (Antibacterial, Antifungal, Antiparasitic, and other sources) peptide sequence curated from Peptipedia, Antifungipept, dbAMP 3.0, and other sources, with an available 3D structural model.
Sequence
RWKVFKKIERMGQHIRDGIIKAGPAVAVVGQASTIISG
Physicochemical Analysis
C185H310N56O48S1
NCLY
I
4118.90
11.53
8
2
17
+5
7.19
0.068
102.63
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
133.53
5
Residue Composition
number
4
A
3
R
0
N
1
D
0
C
1
E
2
Q
5
G
1
H
6
I
0
L
4
K
1
M
1
F
1
P
2
S
1
T
1
W
0
Y
4
V
Amino Acid Distribution
A: 4 R: 3 N: 0 D: 1 C: 0 E: 1 Q: 2 G: 5 H: 1 I: 6 L: 0 K: 4 M: 1 F: 1 P: 1 S: 2 T: 1 W: 1 Y: 0 V: 4
Chemical Descriptors
38
C185H310N56O48S1
4118.90
11.53
+5
7.19
0.068
Evidence Records 5 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

It exhibited significant (P
Evidence 2 Activity

Activity

Antifungal

Source & Reference

Antifungipept

Other

It exhibited significant (P
Evidence 3 Activity

Activity

Antiparasitic

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiparasitic
dbAMP 3.0 classified under the Anti-parasitic function class.
It exhibited significant (P
Evidence 4 Activity

Activity

<10% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
<10% Hemolysis | 100 | µM | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum. | Parasitol Res | 2019
Evidence 5 Activity

Activity

15% Hemolysis
Toxicity
100 µM
Hemolytic Cytotoxic
15% Hemolysis | 100 | µM | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
The Drosophila melanogaster antimicrobial peptides Mtk-1 and Mtk-2 are active against the malarial parasite Plasmodium falciparum. | Parasitol Res | 2019