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Peptide record

TPDB25419

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB25419
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RWKRINRQWFFWQRNIRKWR
Physicochemical Analysis
C140H206N48O25
ADCEGHLMPSTYV
R
2961.48
13.10
8
0
8
+8
-1.44
-1.890
39.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
742.87
4
Residue Composition
number
0
A
6
R
2
N
0
D
0
C
0
E
2
Q
0
G
0
H
2
I
0
L
2
K
0
M
2
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 2 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 0 I: 2 L: 0 K: 2 M: 0 F: 2 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
20
C140H206N48O25
2961.48
13.10
+8
-1.44
-1.890
Evidence Records 3 records
Evidence 1 Activity

Activity

LC50
Toxicity
61.8±0.1 µM
Cytotoxic
LC50 | 61.8±0.1 | µM | target cell: Human dermal fibroblasts

Target

Human dermal fibroblasts

Source & Reference

NA
DBAASP
Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine. | Biochim Biophys Acta | 2015
Evidence 2 Activity

Activity

5% Killing
Toxicity
20 µM
Cytotoxic
5% Killing | 20 | µM | target cell: Human epidermal melanocytes

Target

Human epidermal melanocytes

Source & Reference

NA
DBAASP
Human lactoferricin derived di-peptides deploying loop structures induce apoptosis specifically in cancer cells through targeting membranous phosphatidylserine. | Biochim Biophys Acta | 2015
Evidence 3 Activity

Activity

LC50
Toxicity
61.8
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Normal Human Dermal Fibroblasts (NHDF): LC50=61.8±0.1 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Biochim Biophys Acta. 2015 Nov 1848(11 Pt A):2918-31.