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Peptide record

TPDB25391

Antibacterial Anticancer Toxicity standard
12 amino acids
Basic Information
3D PDB MODEL
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TPDB25391
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 12-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RWFKFPGRWFKF
Physicochemical Analysis
C89H116N22O13
ANDCEQHILMSTYV
F
1702.04
12.42
4
0
6
+4
-4.16
-0.783
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
646.28
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
0
L
2
K
0
M
4
F
1
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 0 K: 2 M: 0 F: 4 P: 1 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
12
C89H116N22O13
1702.04
12.42
+4
-4.16
-0.783
Evidence Records 3 records
Evidence 1 Activity

Activity

4% Hemolysis
Toxicity
256 µM
Hemolytic Cytotoxic
4% Hemolysis | 256 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Cross-Strand Interaction, Central Bending, and Sequence Pattern Act as Biomodulators of Simplified β-Hairpin Antimicrobial Amphiphiles. | Small | 2021
Evidence 2 Activity

Activity

10% Killing
Toxicity
64 µM
Cytotoxic
10% Killing | 64 | µM | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Cross-Strand Interaction, Central Bending, and Sequence Pattern Act as Biomodulators of Simplified β-Hairpin Antimicrobial Amphiphiles. | Small | 2021
Evidence 3 Activity

Activity

10% Killing
Toxicity
>128 µM
Cytotoxic
10% Killing | >128 | µM | target cell: Intestinal Porcine Epithelial Cells IPEC-J2

Target

Intestinal Porcine Epithelial Cells IPEC-J2

Source & Reference

NA
DBAASP
Cross-Strand Interaction, Central Bending, and Sequence Pattern Act as Biomodulators of Simplified β-Hairpin Antimicrobial Amphiphiles. | Small | 2021