TPDB25374

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.0 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP

Other

Source Activity Label	Source Definition
Antibacterial	dbAMP classified as Antibacterial under the Anti-bacterial function class.

Evidence Text

Active against E. coli (MIC 4.0 ug/ml), P. aeruginosa (MIC 2.0 ug/ml), K. pneumonia (MIC 4.0 ug/ml), E. faecium (MIC 2.0 ug/ml),

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.0 µg/mL

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli (MIC 4.0 ug/ml), P. aeruginosa (MIC 2.0 ug/ml), K. pneumonia (MIC 4.0 ug/ml), E. faecium (MIC 2.0 ug/ml), S. aureus (MIC 1.0 ug/ml), and

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4.0 µg/mL

Target

Target Organism K. pneumonia

Source & Reference

Database Source dbAMP

Other

Evidence Text

Active against E. coli (MIC 4.0 ug/ml), P. aeruginosa (MIC 2.0 ug/ml), K. pneumonia (MIC 4.0 ug/ml), E. faecium (MIC 2.0 ug/ml), S. aureus (MIC 1.0 ug/ml), and C. acnes (MIC 2.0 ug/ml). Als

Evidence 4 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.0 µg/mL

Target

Target Organism E. faecium

Source & Reference

Database Source dbAMP

Other

Evidence Text

nst E. coli (MIC 4.0 ug/ml), P. aeruginosa (MIC 2.0 ug/ml), K. pneumonia (MIC 4.0 ug/ml), E. faecium (MIC 2.0 ug/ml), S. aureus (MIC 1.0 ug/ml), and C. acnes (MIC 2.0 ug/ml). Also active against fungi C. al

Evidence 5 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 1.0 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP

Other

Evidence Text

P. aeruginosa (MIC 2.0 ug/ml), K. pneumonia (MIC 4.0 ug/ml), E. faecium (MIC 2.0 ug/ml), S. aureus (MIC 1.0 ug/ml), and C. acnes (MIC 2.0 ug/ml). Also active against fungi C. albicans Y-326 or Y-6359 (MIC

Evidence 6 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2.0 µg/mL

Target

Target Organism C. acnes

Source & Reference

Database Source dbAMP

Other

Evidence Text

K. pneumonia (MIC 4.0 ug/ml), E. faecium (MIC 2.0 ug/ml), S. aureus (MIC 1.0 ug/ml), and C. acnes (MIC 2.0 ug/ml). Also active against fungi C. albicans Y-326 or Y-6359 (MIC 8-16 ug/ml), C. parapsilosis

Evidence 7 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8-16 µg/mL

Target

Target Organism Candida albicans Y-326 or Y-6359

Source & Reference

Database Source dbAMP

Other

Evidence Text

g/ml), S. aureus (MIC 1.0 ug/ml), and C. acnes (MIC 2.0 ug/ml). Also active against fungi C. albicans Y-326 or Y-6359 (MIC 8-16 ug/ml), C. parapsilosis Y-1761 or Y-1763 (MIC 2-32 ug/ml), C. krusei Y-27803 or Y-27825 (MIC 16-

Evidence 8 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2-32 µg/mL

Target

Target Organism C. parapsilosis Y-1761 or Y-1763

Source & Reference

Database Source dbAMP

Other

Evidence Text

(MIC 2.0 ug/ml). Also active against fungi C. albicans Y-326 or Y-6359 (MIC 8-16 ug/ml), C. parapsilosis Y-1761 or Y-1763 (MIC 2-32 ug/ml), C. krusei Y-27803 or Y-27825 (MIC 16-32 ug/ml), A. fumigatus 9648 or 9651 (MIC 64 ug/ml)

Evidence 9 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 16-32 µg/mL

Target

Target Organism C. krusei Y-27803 or Y-27825

Source & Reference

Database Source dbAMP

Other

Evidence Text

cans Y-326 or Y-6359 (MIC 8-16 ug/ml), C. parapsilosis Y-1761 or Y-1763 (MIC 2-32 ug/ml), C. krusei Y-27803 or Y-27825 (MIC 16-32 ug/ml), A. fumigatus 9648 or 9651 (MIC 64 ug/ml), A. flavus MYA-3651 or MYA-1004 (MIC 64 ug/ml),

Evidence 10 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µg/mL

Target

Target Organism A. fumigatus 9648 or 9651

Source & Reference

Database Source dbAMP

Other

Evidence Text

ilosis Y-1761 or Y-1763 (MIC 2-32 ug/ml), C. krusei Y-27803 or Y-27825 (MIC 16-32 ug/ml), A. fumigatus 9648 or 9651 (MIC 64 ug/ml), A. flavus MYA-3651 or MYA-1004 (MIC 64 ug/ml), A. corymbifera NRRL 6251 (MIC2 ug/ml), F.

Evidence 11 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µg/mL

Target

Target Organism A. flavus MYA-3651 or MYA-1004

Source & Reference

Database Source dbAMP

Other

Evidence Text

C. krusei Y-27803 or Y-27825 (MIC 16-32 ug/ml), A. fumigatus 9648 or 9651 (MIC 64 ug/ml), A. flavus MYA-3651 or MYA-1004 (MIC 64 ug/ml), A. corymbifera NRRL 6251 (MIC2 ug/ml), F. solani NRRL 28548 (MIC 2 ug/ml), M. circinello

Evidence 12 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism A. corymbifera NRRL 6251

Source & Reference

Database Source dbAMP

Other

Evidence Text

A. fumigatus 9648 or 9651 (MIC 64 ug/ml), A. flavus MYA-3651 or MYA-1004 (MIC 64 ug/ml), A. corymbifera NRRL 6251 (MIC2 ug/ml), F. solani NRRL 28548 (MIC 2 ug/ml), M. circinelloides NRRL 3631 (MIC 64 ug/ml).

Evidence 13 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 2 µg/mL

Target

Target Organism F. solani NRRL 28548

Source & Reference

Database Source dbAMP

Other

Evidence Text

l), A. flavus MYA-3651 or MYA-1004 (MIC 64 ug/ml), A. corymbifera NRRL 6251 (MIC2 ug/ml), F. solani NRRL 28548 (MIC 2 ug/ml), M. circinelloides NRRL 3631 (MIC 64 ug/ml).

Evidence 14 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 64 µg/mL

Target

Target Organism M. circinelloides NRRL 3631

Source & Reference

Database Source dbAMP

Other

Evidence Text

MIC 64 ug/ml), A. corymbifera NRRL 6251 (MIC2 ug/ml), F. solani NRRL 28548 (MIC 2 ug/ml), M. circinelloides NRRL 3631 (MIC 64 ug/ml).

Evidence 15 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.0 µg/mL

Target

Target Organism Escherichia coli

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Source Activity Label	Source Definition
Antifungal	dbAMP classified under the Anti-fungal function class.

Evidence Text

Active against E. coli (MIC 4.0 ug/ml), P. aeruginosa (MIC 2.0 ug/ml), K. pneumonia (MIC 4.0 ug/ml), E. faecium (MIC 2.0 ug/ml),

Evidence 16 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.0 µg/mL

Target

Target Organism Pseudomonas aeruginosa

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 4.0 ug/ml), P. aeruginosa (MIC 2.0 ug/ml), K. pneumonia (MIC 4.0 ug/ml), E. faecium (MIC 2.0 ug/ml), S. aureus (MIC 1.0 ug/ml), and

Evidence 17 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 4.0 µg/mL

Target

Target Organism K. pneumonia

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

Active against E. coli (MIC 4.0 ug/ml), P. aeruginosa (MIC 2.0 ug/ml), K. pneumonia (MIC 4.0 ug/ml), E. faecium (MIC 2.0 ug/ml), S. aureus (MIC 1.0 ug/ml), and C. acnes (MIC 2.0 ug/ml). Als

Evidence 18 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.0 µg/mL

Target

Target Organism E. faecium

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

nst E. coli (MIC 4.0 ug/ml), P. aeruginosa (MIC 2.0 ug/ml), K. pneumonia (MIC 4.0 ug/ml), E. faecium (MIC 2.0 ug/ml), S. aureus (MIC 1.0 ug/ml), and C. acnes (MIC 2.0 ug/ml). Also active against fungi C. al

Evidence 19 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 1.0 µg/mL

Target

Target Organism Staphylococcus aureus

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

P. aeruginosa (MIC 2.0 ug/ml), K. pneumonia (MIC 4.0 ug/ml), E. faecium (MIC 2.0 ug/ml), S. aureus (MIC 1.0 ug/ml), and C. acnes (MIC 2.0 ug/ml). Also active against fungi C. albicans Y-326 or Y-6359 (MIC

Evidence 20 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2.0 µg/mL

Target

Target Organism C. acnes

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

K. pneumonia (MIC 4.0 ug/ml), E. faecium (MIC 2.0 ug/ml), S. aureus (MIC 1.0 ug/ml), and C. acnes (MIC 2.0 ug/ml). Also active against fungi C. albicans Y-326 or Y-6359 (MIC 8-16 ug/ml), C. parapsilosis

Evidence 21 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 8-16 µg/mL

Target

Target Organism Candida albicans Y-326 or Y-6359

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

g/ml), S. aureus (MIC 1.0 ug/ml), and C. acnes (MIC 2.0 ug/ml). Also active against fungi C. albicans Y-326 or Y-6359 (MIC 8-16 ug/ml), C. parapsilosis Y-1761 or Y-1763 (MIC 2-32 ug/ml), C. krusei Y-27803 or Y-27825 (MIC 16-

Evidence 22 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2-32 µg/mL

Target

Target Organism C. parapsilosis Y-1761 or Y-1763

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

(MIC 2.0 ug/ml). Also active against fungi C. albicans Y-326 or Y-6359 (MIC 8-16 ug/ml), C. parapsilosis Y-1761 or Y-1763 (MIC 2-32 ug/ml), C. krusei Y-27803 or Y-27825 (MIC 16-32 ug/ml), A. fumigatus 9648 or 9651 (MIC 64 ug/ml)

Evidence 23 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 16-32 µg/mL

Target

Target Organism C. krusei Y-27803 or Y-27825

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

cans Y-326 or Y-6359 (MIC 8-16 ug/ml), C. parapsilosis Y-1761 or Y-1763 (MIC 2-32 ug/ml), C. krusei Y-27803 or Y-27825 (MIC 16-32 ug/ml), A. fumigatus 9648 or 9651 (MIC 64 ug/ml), A. flavus MYA-3651 or MYA-1004 (MIC 64 ug/ml),

Evidence 24 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 64 µg/mL

Target

Target Organism A. fumigatus 9648 or 9651

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

ilosis Y-1761 or Y-1763 (MIC 2-32 ug/ml), C. krusei Y-27803 or Y-27825 (MIC 16-32 ug/ml), A. fumigatus 9648 or 9651 (MIC 64 ug/ml), A. flavus MYA-3651 or MYA-1004 (MIC 64 ug/ml), A. corymbifera NRRL 6251 (MIC2 ug/ml), F.

Evidence 25 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 64 µg/mL

Target

Target Organism A. flavus MYA-3651 or MYA-1004

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

C. krusei Y-27803 or Y-27825 (MIC 16-32 ug/ml), A. fumigatus 9648 or 9651 (MIC 64 ug/ml), A. flavus MYA-3651 or MYA-1004 (MIC 64 ug/ml), A. corymbifera NRRL 6251 (MIC2 ug/ml), F. solani NRRL 28548 (MIC 2 ug/ml), M. circinello

Evidence 26 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism A. corymbifera NRRL 6251

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

A. fumigatus 9648 or 9651 (MIC 64 ug/ml), A. flavus MYA-3651 or MYA-1004 (MIC 64 ug/ml), A. corymbifera NRRL 6251 (MIC2 ug/ml), F. solani NRRL 28548 (MIC 2 ug/ml), M. circinelloides NRRL 3631 (MIC 64 ug/ml).

Evidence 27 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 2 µg/mL

Target

Target Organism F. solani NRRL 28548

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

l), A. flavus MYA-3651 or MYA-1004 (MIC 64 ug/ml), A. corymbifera NRRL 6251 (MIC2 ug/ml), F. solani NRRL 28548 (MIC 2 ug/ml), M. circinelloides NRRL 3631 (MIC 64 ug/ml).

Evidence 28 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antifungal

Activity Measurement 64 µg/mL

Target

Target Organism M. circinelloides NRRL 3631

Source & Reference

Database Source dbAMP CAFPdb Antifungipept

Other

Evidence Text

MIC 64 ug/ml), A. corymbifera NRRL 6251 (MIC2 ug/ml), F. solani NRRL 28548 (MIC 2 ug/ml), M. circinelloides NRRL 3631 (MIC 64 ug/ml).

Evidence 29 Activity

Activity

Activity Endpoint 10% Cell death

Detail Source Activity Toxicity

Activity Measurement 276 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

10% Cell death | 276 | µg/mL | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Designed Antimicrobial Peptides for Recurrent Vulvovaginal Candidiasis Treatment. | Antimicrob Agents Chemother | 2019

Evidence 30 Activity

Activity

Activity Endpoint 10% Cell death

Detail Source Activity Toxicity

Activity Measurement 64 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

10% Cell death | 64 | µg/mL | target cell: Mouse fibroblasts L929

Target

Target Cell Mouse fibroblasts L929

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Designed Antimicrobial Peptides Against Trauma-Related Cutaneous Invasive Fungal Wound Infections. | J Fungi (Basel) | 2020

Evidence 31 Activity

Activity

Activity Endpoint 50% Cell death

Detail Source Activity Toxicity

Activity Measurement 519 µg/mL

Toxicity Type Cytotoxic

Toxicity Raw

50% Cell death | 519 | µg/mL | target cell: Human keratinocytes HaCat

Target

Target Cell Human keratinocytes HaCat

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Designed Antimicrobial Peptides for Topical Treatment of Antibiotic Resistant Acne Vulgaris. | Antibiotics (Basel) | 2020