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Peptide record

TPDB25373

Antibacterial Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
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TPDB25373
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RWAVYAYVRVRGVLVRYRRAW
Physicochemical Analysis
C127H195N41O25
NDCEQHIKMFPST
R
2696.21
12.11
6
0
14
+6
-2.37
-0.138
101.90
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
15470
573.77
3
Residue Composition
number
3
A
6
R
0
N
0
D
0
C
0
E
0
Q
1
G
0
H
0
I
1
L
0
K
0
M
0
F
0
P
0
S
0
T
2
W
3
Y
5
V
Amino Acid Distribution
A: 3 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 0 I: 0 L: 1 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 2 Y: 3 V: 5
Chemical Descriptors
21
C127H195N41O25
2696.21
12.11
+6
-2.37
-0.138
Evidence Records 3 records
Evidence 1 Activity

Activity

MIC
Antibacterial
4.0 µM

Target

Escherichia coli

Source & Reference

NA

Other

active against E. coli (MIC 4.0 uM) and L. monocytogenes (MIC 3.6 uM). The MIC values are comparable to Ar-1 (3.3 and 2.2 uM,
Evidence 2 Activity

Activity

MIC
Antibacterial
3.6 µM

Target

L. monocytogenes

Source & Reference

NA

Other

active against E. coli (MIC 4.0 uM) and L. monocytogenes (MIC 3.6 uM). The MIC values are comparable to Ar-1 (3.3 and 2.2 uM, respectively).
Evidence 3 Activity

Activity

10% Hemolysis
Toxicity
11.1±2.3 µM
Hemolytic Cytotoxic
10% Hemolysis | 11.1±2.3 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Antimicrobial Peptide Arenicin-1 Derivative Ar-1-(C/A) as Complement System Modulator. | Mar Drugs | 2020