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Peptide record

TPDB25366

Antibacterial Anticancer Toxicity standard
20 amino acids
Basic Information
3D PDB MODEL
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TPDB25366
Antibacterial Anticancer Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia
standard
No
A 20-aa standard natural multi-activity (Antibacterial, Anticancer, and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RVFKKFHPIYHRVWRLWGHL
Physicochemical Analysis
C132H191N39O22
ANDCEQMST
RH
2676.22
12.14
8
0
10
+5
-0.44
-0.495
87.50
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
12490
466.70
1
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
1
G
3
H
1
I
2
L
2
K
0
M
2
F
1
P
0
S
0
T
2
W
1
Y
2
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 1 H: 3 I: 1 L: 2 K: 2 M: 0 F: 2 P: 1 S: 0 T: 0 W: 2 Y: 1 V: 2
Chemical Descriptors
20
C132H191N39O22
2676.22
12.14
+5
-0.44
-0.495
Evidence Records 3 records
Evidence 1 Activity

Activity

EC50
Toxicity
56±7 µM
Cytotoxic
EC50 | 56±7 | µM | target cell: Human dermal microvascular endothelial cells HDME

Target

Human dermal microvascular endothelial cells HDME

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 2 Activity

Activity

5% Hemolysis
Toxicity
>200 µM
Hemolytic Cytotoxic
5% Hemolysis | >200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
In silico design and optimization of selective membranolytic anticancer peptides. | Sci Rep | 2019
Evidence 3 Activity

Activity

HC50
Toxicity
200 µM
Hemolytic Cytotoxic
Hemolytic_activity: Human erythrocytes: HC50>200 µM | Cytotoxicity: HDMEC: EC50=56 ± 7 µM

Target

erythrocytes

Source & Reference

NA
DRAMP
Sci Rep. 2019 Aug 2 9(1):11282.