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Peptide record

TPDB25267

Antibacterial Toxicity standard
21 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB25267
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 21-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RSPRVCIRVCRNGVCYRRCWG
Physicochemical Analysis
C105H175N41O25S4
ADEQHLKMFT
R
2540.04
10.92
6
0
6
+6
2.03
-0.419
60.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
7240
285.03
7
Residue Composition
number
0
A
6
R
1
N
0
D
4
C
0
E
0
Q
2
G
0
H
1
I
0
L
0
K
0
M
0
F
1
P
1
S
0
T
1
W
1
Y
3
V
Amino Acid Distribution
A: 0 R: 6 N: 1 D: 0 C: 4 E: 0 Q: 0 G: 2 H: 0 I: 1 L: 0 K: 0 M: 0 F: 0 P: 1 S: 1 T: 0 W: 1 Y: 1 V: 3
Chemical Descriptors
21
C105H175N41O25S4
2540.04
10.92
+6
2.03
-0.419
Evidence Records 9 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1 µM

Target

M. luteus B-1314

Source & Reference

NA

Other

active against Gram+ M. luteus B-1314 (MIC 1 uM), S. aureus 209P (MIC 4 uM), B. subtilis B-886 (MIC 8 uM), E. coli ML-35p or ATTC 25922 or
Evidence 2 Activity

Activity

MIC
Antibacterial
4 µM

Target

Staphylococcus aureus 209P

Source & Reference

NA

Other

active against Gram+ M. luteus B-1314 (MIC 1 uM), S. aureus 209P (MIC 4 uM), B. subtilis B-886 (MIC 8 uM), E. coli ML-35p or ATTC 25922 or CI 3600 or CI 214 (MIC 0.2
Evidence 3 Activity

Activity

MIC
Antibacterial
8 µM

Target

B. subtilis B-886

Source & Reference

NA

Other

active against Gram+ M. luteus B-1314 (MIC 1 uM), S. aureus 209P (MIC 4 uM), B. subtilis B-886 (MIC 8 uM), E. coli ML-35p or ATTC 25922 or CI 3600 or CI 214 (MIC 0.25 uM), E. cloacae CI 4172 (MIC
Evidence 4 Activity

Activity

MIC
Antibacterial
0.25 µM

Target

Escherichia coli ML-35p or ATTC 25922 or CI 3600 or CI 214

Source & Reference

NA

Other

am+ M. luteus B-1314 (MIC 1 uM), S. aureus 209P (MIC 4 uM), B. subtilis B-886 (MIC 8 uM), E. coli ML-35p or ATTC 25922 or CI 3600 or CI 214 (MIC 0.25 uM), E. cloacae CI 4172 (MIC 2 uM), A. baumanii CI 2675 (MIC 0.125 uM), P. aeruginosa PAO1 (M
Evidence 5 Activity

Activity

MIC
Antibacterial
2 µM

Target

Enterobacter cloacae CI 4172

Source & Reference

NA

Other

btilis B-886 (MIC 8 uM), E. coli ML-35p or ATTC 25922 or CI 3600 or CI 214 (MIC 0.25 uM), E. cloacae CI 4172 (MIC 2 uM), A. baumanii CI 2675 (MIC 0.125 uM), P. aeruginosa PAO1 (MIC 1 uM), and K. pneumonia ATCC
Evidence 6 Activity

Activity

MIC
Antibacterial
0.125 µM

Target

A. baumanii CI 2675

Source & Reference

NA

Other

i ML-35p or ATTC 25922 or CI 3600 or CI 214 (MIC 0.25 uM), E. cloacae CI 4172 (MIC 2 uM), A. baumanii CI 2675 (MIC 0.125 uM), P. aeruginosa PAO1 (MIC 1 uM), and K. pneumonia ATCC 700603 (MIC 2 uM).
Evidence 7 Activity

Activity

MIC
Antibacterial
1 µM

Target

Pseudomonas aeruginosa PAO1

Source & Reference

NA

Other

CI 214 (MIC 0.25 uM), E. cloacae CI 4172 (MIC 2 uM), A. baumanii CI 2675 (MIC 0.125 uM), P. aeruginosa PAO1 (MIC 1 uM), and K. pneumonia ATCC 700603 (MIC 2 uM).
Evidence 8 Activity

Activity

MIC
Antibacterial
2 µM

Target

K. pneumonia ATCC 700603

Source & Reference

NA

Other

I 4172 (MIC 2 uM), A. baumanii CI 2675 (MIC 0.125 uM), P. aeruginosa PAO1 (MIC 1 uM), and K. pneumonia ATCC 700603 (MIC 2 uM).
Evidence 9 Activity

Activity

<5% Hemolysis
Toxicity
128 µM
Hemolytic Cytotoxic
<5% Hemolysis | 128 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Mechanism of Action and Therapeutic Potential of the β-Hairpin Antimicrobial Peptide Capitellacin from the Marine Polychaeta Capitella teleta | Mar Drugs | 2022