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Peptide record

TPDB25264

Antibacterial Anticancer Antifungal Toxicity standard
38 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB25264
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb
standard
No
A 38-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and CAFPdb, with an available 3D structural model.
Sequence
RSKKWRKIEKRVKKIFEKTKEALPVIQGVATIVGAVGR
Physicochemical Analysis
C198H344N60O49
NDCHMY
K
4349.28
11.62
12
3
15
+9
13.75
-0.476
97.37
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
5500
126.46
4
Residue Composition
number
3
A
4
R
0
N
0
D
0
C
3
E
1
Q
3
G
0
H
4
I
1
L
8
K
0
M
1
F
1
P
1
S
2
T
1
W
0
Y
5
V
Amino Acid Distribution
A: 3 R: 4 N: 0 D: 0 C: 0 E: 3 Q: 1 G: 3 H: 0 I: 4 L: 1 K: 8 M: 0 F: 1 P: 1 S: 1 T: 2 W: 1 Y: 0 V: 5
Chemical Descriptors
38
C198H344N60O49
4349.28
11.62
+9
13.75
-0.476
Evidence Records 23 records
Evidence 1 Activity

Activity

MIC
Antibacterial
3.12 µg/mL

Target

Escherichia coli ATCC 25922 or ATCC 35218

Source & Reference

NA

Other

active against Gram- E. coli ATCC 25922 or ATCC 35218 (MIC 3.12 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/m
Evidence 2 Activity

Activity

MIC
Antibacterial
6.25 µg/mL

Target

Pseudomonas aeruginosa ATCC 105663

Source & Reference

NA

Other

active against Gram- E. coli ATCC 25922 or ATCC 35218 (MIC 3.12 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S. aureus ATCC 29213 (MIC 50 ug/ml
Evidence 3 Activity

Activity

MIC
Antibacterial
3.12 µg/mL

Target

Klebsiella pneumoniae ATCC BAA 170513

Source & Reference

NA

Other

li ATCC 25922 or ATCC 35218 (MIC 3.12 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S. aureus ATCC 29213 (MIC 50 ug/ml), E. faecalis ATCC 29212 (MIC 25 ug/ml), fungi
Evidence 4 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

Staphylococcus aureus ATCC 29213

Source & Reference

NA

Other

inosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S. aureus ATCC 29213 (MIC 50 ug/ml), E. faecalis ATCC 29212 (MIC 25 ug/ml), fungi C. parapsilosis ATCC 22019 (MIC 50 ug/ml) (
Evidence 5 Activity

Activity

MIC
Antibacterial
25 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

NA

Other

. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S. aureus ATCC 29213 (MIC 50 ug/ml), E. faecalis ATCC 29212 (MIC 25 ug/ml), fungi C. parapsilosis ATCC 22019 (MIC 50 ug/ml) (see ref). Also showed antifungal activi
Evidence 6 Activity

Activity

MIC
Antibacterial
50 µg/mL

Target

C. parapsilosis ATCC 22019

Source & Reference

NA

Other

, Gram+ S. aureus ATCC 29213 (MIC 50 ug/ml), E. faecalis ATCC 29212 (MIC 25 ug/ml), fungi C. parapsilosis ATCC 22019 (MIC 50 ug/ml) (see ref). Also showed antifungal activity against 20 strains M. furfur (MIC 12.5-50 uM),
Evidence 7 Activity

Activity

MIC
Antibacterial
12.5-50 µM

Target

M. furfur

Source & Reference

NA

Other

s ATCC 22019 (MIC 50 ug/ml) (see ref). Also showed antifungal activity against 20 strains M. furfur (MIC 12.5-50 uM), 5 strains M. pachydermatis (MIC 12.5-50 uM), 3 strains M. sympodialis (MIC 12.5-50 uM) (
Evidence 8 Activity

Activity

MIC
Antibacterial
12.5-50 µM

Target

M. pachydermatis

Source & Reference

NA

Other

Also showed antifungal activity against 20 strains M. furfur (MIC 12.5-50 uM), 5 strains M. pachydermatis (MIC 12.5-50 uM), 3 strains M. sympodialis (MIC 12.5-50 uM) ( Molina Pineda et al., 2025 ).
Evidence 9 Activity

Activity

MIC
Antibacterial
12.5-50 µM

Target

M. sympodialis

Source & Reference

NA

Other

trains M. furfur (MIC 12.5-50 uM), 5 strains M. pachydermatis (MIC 12.5-50 uM), 3 strains M. sympodialis (MIC 12.5-50 uM) ( Molina Pineda et al., 2025 ).
Evidence 10 Activity

Activity

MIC
Antifungal
3.12 µg/mL

Target

Escherichia coli ATCC 25922 or ATCC 35218

Source & Reference

CAFPdb

Other

active against Gram- E. coli ATCC 25922 or ATCC 35218 (MIC 3.12 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/m
Evidence 11 Activity

Activity

MIC
Antifungal
6.25 µg/mL

Target

Pseudomonas aeruginosa ATCC 105663

Source & Reference

CAFPdb

Other

active against Gram- E. coli ATCC 25922 or ATCC 35218 (MIC 3.12 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S. aureus ATCC 29213 (MIC 50 ug/ml
Evidence 12 Activity

Activity

MIC
Antifungal
3.12 µg/mL

Target

Klebsiella pneumoniae ATCC BAA 170513

Source & Reference

CAFPdb

Other

li ATCC 25922 or ATCC 35218 (MIC 3.12 ug/ml), P. aeruginosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S. aureus ATCC 29213 (MIC 50 ug/ml), E. faecalis ATCC 29212 (MIC 25 ug/ml), fungi
Evidence 13 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

Staphylococcus aureus ATCC 29213

Source & Reference

CAFPdb

Other

inosa ATCC 105663 (MIC 6.25 ug/ml), K. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S. aureus ATCC 29213 (MIC 50 ug/ml), E. faecalis ATCC 29212 (MIC 25 ug/ml), fungi C. parapsilosis ATCC 22019 (MIC 50 ug/ml) (
Evidence 14 Activity

Activity

MIC
Antifungal
25 µg/mL

Target

Enterococcus faecalis ATCC 29212

Source & Reference

CAFPdb

Other

. pneumoniae ATCC BAA 170513 (MIC 3.12 ug/ml), Gram+ S. aureus ATCC 29213 (MIC 50 ug/ml), E. faecalis ATCC 29212 (MIC 25 ug/ml), fungi C. parapsilosis ATCC 22019 (MIC 50 ug/ml) (see ref). Also showed antifungal activi
Evidence 15 Activity

Activity

MIC
Antifungal
50 µg/mL

Target

C. parapsilosis ATCC 22019

Source & Reference

CAFPdb

Other

, Gram+ S. aureus ATCC 29213 (MIC 50 ug/ml), E. faecalis ATCC 29212 (MIC 25 ug/ml), fungi C. parapsilosis ATCC 22019 (MIC 50 ug/ml) (see ref). Also showed antifungal activity against 20 strains M. furfur (MIC 12.5-50 uM),
Evidence 16 Activity

Activity

MIC
Antifungal
12.5-50 µM

Target

M. furfur

Source & Reference

CAFPdb

Other

s ATCC 22019 (MIC 50 ug/ml) (see ref). Also showed antifungal activity against 20 strains M. furfur (MIC 12.5-50 uM), 5 strains M. pachydermatis (MIC 12.5-50 uM), 3 strains M. sympodialis (MIC 12.5-50 uM) (
Evidence 17 Activity

Activity

MIC
Antifungal
12.5-50 µM

Target

M. pachydermatis

Source & Reference

CAFPdb

Other

Also showed antifungal activity against 20 strains M. furfur (MIC 12.5-50 uM), 5 strains M. pachydermatis (MIC 12.5-50 uM), 3 strains M. sympodialis (MIC 12.5-50 uM) ( Molina Pineda et al., 2025 ).
Evidence 18 Activity

Activity

MIC
Antifungal
12.5-50 µM

Target

M. sympodialis

Source & Reference

CAFPdb

Other

trains M. furfur (MIC 12.5-50 uM), 5 strains M. pachydermatis (MIC 12.5-50 uM), 3 strains M. sympodialis (MIC 12.5-50 uM) ( Molina Pineda et al., 2025 ).
Evidence 19 Activity

Activity

50% Hemolysis
Toxicity
187.5 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 187.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Novel antimicrobial cecropins derived from O. curvicornis and D. satanas dung beetles. | Peptides | 2021
Evidence 20 Activity

Activity

IC50
Toxicity
124.1 µg/mL
Cytotoxic
IC50 | 124.1 | µg/mL | target cell: Vero cells

Target

Vero cells

Source & Reference

NA
DBAASP
Novel antimicrobial cecropins derived from O. curvicornis and D. satanas dung beetles. | Peptides | 2021
Evidence 21 Activity

Activity

IC50
Toxicity
172.7 µg/mL
Cytotoxic
IC50 | 172.7 | µg/mL | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Novel antimicrobial cecropins derived from O. curvicornis and D. satanas dung beetles. | Peptides | 2021
Evidence 22 Activity

Activity

IC50
Toxicity
406.5 µg/mL
Cytotoxic
IC50 | 406.5 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Novel antimicrobial cecropins derived from O. curvicornis and D. satanas dung beetles. | Peptides | 2021
Evidence 23 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Peptides. 2021 Nov 145:170626.