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Peptide record

TPDB25246

Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB25246
Antibacterial Anticancer Antifungal Antiparasitic Antiviral Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP
standard
No
A 6-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, and dbAMP, with an available 3D structural model.
Sequence
RRWWRF
Physicochemical Analysis
C49H67N17O7
ANDCEQGHILKMPSTYV
R
1006.18
12.70
3
0
3
+3
-2.40
-2.083
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
11000
1093.24
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
2
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 2 Y: 0 V: 0
Chemical Descriptors
6
C49H67N17O7
1006.18
12.70
+3
-2.40
-2.083
Evidence Records 20 records
Evidence 1 Activity

Activity

IC50
Antibacterial
5 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP

Other

Source Activity Label Source Definition
Antibacterial
dbAMP classified as Antibacterial under the Anti-bacterial function class.
Active against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also
Evidence 2 Activity

Activity

IC50
Antibacterial
5 µg/mL

Target

S. sanguis

Source & Reference

dbAMP

Other

Active against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also active against E. coli ATC
Evidence 3 Activity

Activity

IC50
Antibacterial
8 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP

Other

Active against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also active against E. coli ATCC 2592, M. luteus, and S
Evidence 4 Activity

Activity

IC50
Antibacterial
39 µg/mL

Target

Candida albicans

Source & Reference

dbAMP

Other

against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also active against E. coli ATCC 2592, M. luteus, and S. cerevisae Ke T et al., 2012 .
Evidence 5 Activity

Activity

IC50
Antifungal
5 µg/mL

Target

Staphylococcus aureus

Source & Reference

dbAMP CAFPdb

Other

Source Activity Label Source Definition
Antifungal
dbAMP classified under the Anti-fungal function class.
Active against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also
Evidence 6 Activity

Activity

IC50
Antifungal
5 µg/mL

Target

S. sanguis

Source & Reference

dbAMP CAFPdb

Other

Active against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also active against E. coli ATC
Evidence 7 Activity

Activity

IC50
Antifungal
8 µg/mL

Target

Escherichia coli

Source & Reference

dbAMP CAFPdb

Other

Active against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also active against E. coli ATCC 2592, M. luteus, and S
Evidence 8 Activity

Activity

IC50
Antifungal
39 µg/mL

Target

Candida albicans

Source & Reference

dbAMP CAFPdb

Other

against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also active against E. coli ATCC 2592, M. luteus, and S. cerevisae Ke T et al., 2012 .
Evidence 9 Activity

Activity

IC50
Antiparasitic
5 µg/mL

Target

Staphylococcus aureus

Source & Reference

NA

Other

Active against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also
Evidence 10 Activity

Activity

IC50
Antiparasitic
5 µg/mL

Target

S. sanguis

Source & Reference

NA

Other

Active against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also active against E. coli ATC
Evidence 11 Activity

Activity

IC50
Antiparasitic
8 µg/mL

Target

Escherichia coli

Source & Reference

NA

Other

Active against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also active against E. coli ATCC 2592, M. luteus, and S
Evidence 12 Activity

Activity

IC50
Antiparasitic
39 µg/mL

Target

Candida albicans

Source & Reference

NA

Other

against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also active against E. coli ATCC 2592, M. luteus, and S. cerevisae Ke T et al., 2012 .
Evidence 13 Activity

Activity

IC50
Antiviral
5 µg/mL

Target

Staphylococcus aureus

Source & Reference

NA

Other

Active against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also
Evidence 14 Activity

Activity

IC50
Antiviral
5 µg/mL

Target

S. sanguis

Source & Reference

NA

Other

Active against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also active against E. coli ATC
Evidence 15 Activity

Activity

IC50
Antiviral
8 µg/mL

Target

Escherichia coli

Source & Reference

NA

Other

Active against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also active against E. coli ATCC 2592, M. luteus, and S
Evidence 16 Activity

Activity

IC50
Antiviral
39 µg/mL

Target

Candida albicans

Source & Reference

NA

Other

against S. aureus (IC50 5 ug/ml), S. sanguis (IC50 5 ug/ml), E. coli (IC50 8 ug/ml), and C. albicans (IC50 39 ug/ml). Also active against E. coli ATCC 2592, M. luteus, and S. cerevisae Ke T et al., 2012 .
Evidence 17 Activity

Activity

Toxicity
Hemolytic
NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. | PLoS One | 2010
Evidence 18 Activity

Activity

IC50
Toxicity
>=65 µM
Cytotoxic
IC50 | >=65 | µM | target cell: Human PBMC

Target

Human PBMC

Source & Reference

NA
DBAASP
Selective anticancer activity of synthetic peptides derived from the host defence peptide tritrpticin. | Biochim Biophys Acta | 2020
Evidence 19 Activity

Activity

Toxicity
Hemolytic Cytotoxic
- | NA | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Serum stabilities of short tryptophan- and arginine-rich antimicrobial peptide analogs. | PLoS One | 2010
Evidence 20 Activity

Activity

% Hemolysis
Toxicity
24 %
Hemolytic
Hemolytic_activity: [Ref.16075425] It has 24% hemolysis at 100 µM against erythrocytes.

Target

erythrocytes

Source & Reference

NA
DRAMP
Chembiochem. 2005 Sep 6(9):1654-1662.##J Appl Bacteriol. 1995 Jan 78(1):39-46.