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Peptide record

TPDB25163

Antibacterial Toxicity modified_plain modified
6 amino acids
Basic Information
3D PDB MODEL
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TPDB25163
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 6-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
RRRXFX
Physicochemical Analysis
C27H47N13O5
ANDCEQGHILKMPSTWYV
R
633.75
12.70
3
0
1
+3
1.30
-1.783
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
3
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
1
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 3 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 1 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C27H47N13O5
633.75
12.70
+3
1.30
-1.783
Evidence Records 2 records
Evidence 1 Activity

Activity

<5% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
<5% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Arg/Trp-Rich Cyclic ?/?-Antimicrobial Peptides: The Roles of H-bonding and Hydrophobic/Hydrophilic Solvent Accessible Surface Areas upon the Activity and Membrane Selectivity. | Chemistry | 2018
Evidence 2 Activity

Activity

27% Hemolysis
Toxicity
200 µM
Hemolytic Cytotoxic
27% Hemolysis | 200 | µM | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Interaction of W-substituted analogs of cyclo-RRRWFW with bacterial lipopolysaccharides: the role of the aromatic cluster in antimicrobial activity. | Antimicrob Agents Chemother | 2011