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Peptide record

TPDB25149

Antibacterial Toxicity modified_plain modified
7 amino acids
Basic Information
3D PDB MODEL
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TPDB25149
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
modified_plain
Yes
A 7-aa modified multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Modified, details unspecified
Sequence
RRRRXXX
Physicochemical Analysis
C24H50N16O5
ANDCEQGHILKMFPSTWYV
R
642.77
12.88
4
0
0
+4
3.24
-2.571
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C24H50N16O5
642.77
12.88
+4
3.24
-2.571
Evidence Records 11 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
145 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 145 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. | J Med Chem | 2022
Evidence 2 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. | J Med Chem | 2022
Evidence 3 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. | J Med Chem | 2022
Evidence 4 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human hepatocyte cells HepaRG

Target

Human hepatocyte cells HepaRG

Source & Reference

NA
DBAASP
Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. | J Med Chem | 2022
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
70 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 70 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. | J Med Chem | 2022
Evidence 6 Activity

Activity

20% Cytotoxicity
Toxicity
50 µg/mL
Cytotoxic
20% Cytotoxicity | 50 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. | J Med Chem | 2022
Evidence 7 Activity

Activity

50% Hemolysis
Toxicity
130 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 130 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. | J Med Chem | 2022
Evidence 8 Activity

Activity

31% Cytotoxicity
Toxicity
250 µg/mL
Cytotoxic
31% Cytotoxicity | 250 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. | J Med Chem | 2022
Evidence 9 Activity

Activity

53% Cytotoxicity
Toxicity
250 µg/mL
Cytotoxic
53% Cytotoxicity | 250 | µg/mL | target cell: Human hepatocyte cells HepaRG

Target

Human hepatocyte cells HepaRG

Source & Reference

NA
DBAASP
Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. | J Med Chem | 2022
Evidence 10 Activity

Activity

50% Hemolysis
Toxicity
80 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 80 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. | J Med Chem | 2022
Evidence 11 Activity

Activity

16% Cytotoxicity
Toxicity
50 µg/mL
Cytotoxic
16% Cytotoxicity | 50 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Small Amphiphilic Peptides: Activity Against a Broad Range of Drug-Resistant Bacteria and Structural Insight into Membranolytic Properties. | J Med Chem | 2022