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Peptide record

TPDB25135

Antibacterial Toxicity standard
9 amino acids
Basic Information
3D PDB MODEL
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TPDB25135
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 9-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RRRRRWWWW
Physicochemical Analysis
C74H102N28O10
ANDCEQGHILKMFPSTYV
R
1543.81
13.00
5
0
4
+5
-3.35
-2.900
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
1425.05
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
9
C74H102N28O10
1543.81
13.00
+5
-3.35
-2.900
Evidence Records 5 records
Evidence 1 Activity

Activity

2% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
2% Cytotoxicity | 100 | µg/mL | target cell: Human fibroblasts MRC-5

Target

Human fibroblasts MRC-5

Source & Reference

NA
DBAASP
Membrane-Active Cyclic Amphiphilic Peptides: Broad-Spectrum Antibacterial Activity Alone and in Combination with Antibiotics. | J Med Chem | 2022
Evidence 2 Activity

Activity

25% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
25% Cytotoxicity | 100 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Membrane-Active Cyclic Amphiphilic Peptides: Broad-Spectrum Antibacterial Activity Alone and in Combination with Antibiotics. | J Med Chem | 2022
Evidence 3 Activity

Activity

9% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
9% Cytotoxicity | 100 | µg/mL | target cell: Human hepatocyte cells HepaRG

Target

Human hepatocyte cells HepaRG

Source & Reference

NA
DBAASP
Membrane-Active Cyclic Amphiphilic Peptides: Broad-Spectrum Antibacterial Activity Alone and in Combination with Antibiotics. | J Med Chem | 2022
Evidence 4 Activity

Activity

30% Cytotoxicity
Toxicity
100 µg/mL
Cytotoxic
30% Cytotoxicity | 100 | µg/mL | target cell: Human skin fibroblasts

Target

Human skin fibroblasts

Source & Reference

NA
DBAASP
Membrane-Active Cyclic Amphiphilic Peptides: Broad-Spectrum Antibacterial Activity Alone and in Combination with Antibiotics. | J Med Chem | 2022
Evidence 5 Activity

Activity

50% Hemolysis
Toxicity
340 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 340 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Membrane-Active Cyclic Amphiphilic Peptides: Broad-Spectrum Antibacterial Activity Alone and in Combination with Antibiotics. | J Med Chem | 2022