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Peptide record

TPDB25131

Antibacterial Toxicity standard
10 amino acids
Basic Information
3D PDB MODEL
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TPDB25131
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 10-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RRRRRRWWWW
Physicochemical Analysis
C80H114N32O11
ANDCEQGHILKMFPSTYV
R
1699.99
13.10
6
0
4
+6
-2.54
-3.060
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
22000
1294.12
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
4
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 4 Y: 0 V: 0
Chemical Descriptors
10
C80H114N32O11
1699.99
13.10
+6
-2.54
-3.060
Evidence Records 1 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
265 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 265 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Membrane-Active Cyclic Amphiphilic Peptides: Broad-Spectrum Antibacterial Activity Alone and in Combination with Antibiotics. | J Med Chem | 2022