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Peptide record

TPDB25125

R9F2 Antibacterial Antifungal Cell-penetrating Peptides standard
11 amino acids
Basic Information
3D PDB MODEL
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TPDB25125
R9F2
Antibacterial Antifungal Cell-penetrating Peptides
Anti-infective peptides Delivery and barrier-penetrating peptides
Peptipedia CPPsite3.0 MLCPP 2.0
standard
No
A 11-aa standard natural multi-activity (Antibacterial, Antifungal, and Cell-penetrating Peptides) peptide sequence curated from Peptipedia, CPPsite3.0, and MLCPP 2.0, with an available 3D structural model.
Chemical: Transferrin (Tf)-modified DiI-labeled Liposomes
Sequence
RRRRRRRRRFF
Physicochemical Analysis
C72H128N38O12
ANDCEQGHILKMPSTWYV
R
1718.06
13.30
9
0
2
+9
5.03
-3.173
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
9
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
2
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 9 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 2 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
11
C72H128N38O12
1718.06
13.30
+9
5.03
-3.173
Free
Transferrin (Tf)-modified DiI-labeled Liposomes
L
Cationic
Linear
Free
N1CCC[C@H]1C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)O
Evidence Records 1 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

bEnd.3, Glial, And Primary Neuronal Cells

Assay & Model

Male/female Sprague Dawley rats and C57BL/6 mice
Male/female Sprague Dawley rats and C57BL/6 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
pDNA
R9F2Tf-liposomes showed a superior ability to induce GFP expression in bEnd.3 (41.4% versus 24.1% for PFTf-lip), glial (25.8% versus 22.9% for PFTf-lip), and primary neuronal cells (13.9% versus 12.0% for PFTf-lip).
Clathrin mediated endocytosis
In vitro and in vivo
CCCCCC
Additional Detail Fields 1 fields
CCCCCC