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Peptide record

TPDB25124

Arg7 R7 Antibacterial Anticancer Antiviral Cell-penetrating Peptides standard
7 amino acids
Basic Information
3D PDB MODEL
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TPDB25124
Arg7 R7
Antibacterial Anticancer Antiviral Cell-penetrating Peptides
Anti-infective peptides Cancer-related peptides Delivery and barrier-penetrating peptides
Peptipedia dbAMP 3.0 CellPPD CellPPD-MOD CPPsite3.0 PerseuCPP
standard
No
A 7-aa standard natural multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from Peptipedia, dbAMP 3.0, CellPPD, and other sources, with an available 3D structural model.
Sequence
RRRRRRR
Physicochemical Analysis
C42H86N28O8
ANDCEQGHILKMFPSTWYV
R
1111.33
13.18
7
0
0
+7
5.67
-4.500
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
7
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 7 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
7
C42H86N28O8
1111.33
13.18
+7
5.67
-4.500
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O NCC(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCC(=O)N)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCC(=O)N)C(=O)O
Evidence Records 7 records
Evidence 1 Activity

Activity

Antibacterial

Source & Reference

NA

Other

Active against fungi. TBA.
Evidence 2 Activity

Activity

Antiviral

Source & Reference

dbAMP 3.0

Other

Source Activity Label Source Definition
Antiviral
dbAMP 3.0 classified under the Anti-viral function class.
Active against fungi. TBA.
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

A549

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Nucleic acid (pDNA)
Cytosol
Significantly effective compared to the other poly-arginines
In vitro
CCCCCCC
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Assay & Model

Female and male B6D2F1 mice
Female and male B6D2F1 mice

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Protein (ESRRB recombinant protein)
Cytoplasm and nucleus
Higher uptake efficiency
Non-endocytic mechanism
In vivo
CCCCCCC
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

Rat Primary Cortical Cultures

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Heparan sulfate receptor-mediated endocytic pathway
In vitro
CCCCCCC
Evidence 6 Activity

Activity

Cell-penetrating Peptides

Target

HeLa, A549,Caco-2, THP-1, and RAW264.7 cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Salmonella phage selz
Late Endosomes/Lysosomes
selzR7 showed a significantly higher (P < 0.05) uptake number of phages than WT selz in A549 cells.
In vitro
CCCCCCCC
Evidence 7 Activity

Activity

Cell-penetrating Peptides

Target

Hek-293T Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Mannosyl erythritol lipid (MEL)-based peptide linker modified Texas red-DHPE-encapsulated LPNVs
Cytosol
The LPNVTat and LPNVArg7 only surrounded the ER when they were dispersed in the cytosol, implying that Tat and Arg7 could lead the NVs towards the ER and nucleus but did not assist their penetration through the ER membrane.
In vitro
CCCCCCCCCCCC
Additional Detail Fields 1 fields
CCCCCCC CCCCCCCC CCCCCCCCCCCC