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Peptide record

TPDB25123

CPP polyarginine (R6) R6-anti-gyrA PNA/scPNA R6 Antibacterial Anticancer Antiviral Cell-penetrating Peptides Toxicity standard
6 amino acids
Basic Information
3D PDB MODEL
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TPDB25123
CPP polyarginine (R6) R6-anti-gyrA PNA/scPNA R6
Antibacterial Anticancer Antiviral Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia dbAMP 3.0 CellPPD CellPPD-MOD CPPsite3.0 MLCPP 2.0 PerseuCPP
standard
No
A 6-aa standard natural multi-activity (Antibacterial, Anticancer, Antiviral, and other sources) peptide sequence curated from Peptipedia, dbAMP 3.0, CellPPD, and other sources, with an available 3D structural model.
Sequence
RRRRRR
Physicochemical Analysis
C36H74N24O7
ANDCEQGHILKMFPSTWYV
R
955.14
13.10
6
0
0
+6
4.86
-4.500
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
6
C36H74N24O7
955.14
13.10
+6
4.86
-4.500
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O N[C@@H](CCSC)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H]([C@@H](C)O)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CC(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H]([C@@H](C)CC)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C)C(=O)N[C@@H](CS)C(=O)NCC(=O)N1CCC[C@H]1C(=O)N1CCC[C@H]1C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](C(C)C)C(=O)O N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)N[C@@H](CC1=C(C(=NC1)C)CC)C(=O)N[C@@H](CCCCN)C(=O)O
Evidence Records 7 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Rat Primary Cortical Cultures

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Heparan sulfate receptor-mediated endocytic pathway
In vitro
CCCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

S. Pyogenes Strains

Assay & Model

G. mellonella Larvae
G. mellonella Larvae

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L
Synthetic
anti-gyrA antisense PNAs and scrambled PNAs [scPNAs]
In vitro and in vivo
CCTTHHHHSSSCSCCSSSSSCC
Evidence 3 Activity

Activity

Cell-penetrating Peptides

Target

Du145, Lncap, And Rwpe1 Cells

Assay & Model

NU/J nude mice (male, 6–8 weeks)
NU/J nude mice (male, 6–8 weeks)

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Cationic
Synthetic
Alexa 488 labelled nanoparticles (nanoSABER probe) loaded with alkyne and legumain substrate AAN
Cytoplasm
Abundant intracellular aggregation of green fluorescent Alexa-alkyne-dimer nanoparticles was observed throughout the cytoplasm of DU145 cells but much less in LNCaP and near-absent in RWPE1 cells.
In-vitro, in-vivo and ex vivo
Evidence 4 Activity

Activity

Cell-penetrating Peptides

Target

Retinal Ganglion Cells (Rgcs), ARPE-19, Hcf Adult Porcine Eyes

Assay & Model

Male Sprague-Dawley rats (200 g)
Male Sprague-Dawley rats (200 g)

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Cationic
Synthetic
5[6]-carboxyfluorescein and Bevacizumab and ranibizumab , anti-VEGF antibodies
Significantly higher uptake than levels in the control
In-vitro, in-vivo and ex vivo
Evidence 5 Activity

Activity

Cell-penetrating Peptides

Target

Raji Cell

Source & Reference

CPPsite3.0
CPPsite3

Other

Natural residues Linear L Cationic
Synthetic
Methotrexate
In vitro
CCCCTTCC
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
>2000 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >2000 | µg/mL | target cell: Rat erythrocytes

Target

Rat erythrocytes

Source & Reference

NA
DBAASP
Synthetic modifications of the immunomodulating peptide thymopentin to confer anti-mycobacterial activity. | Biomaterials | 2014
Evidence 7 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Proc Natl Acad Sci U S A. 2000 Nov 21 97(24):13003-8
Additional Detail Fields 1 fields
CCCCCC CCTTHHHHSSSCSCCSSSSSCC CCCCTTCC