Back to search

Peptide record

TPDB25122

poly-arginine (R5) R5 Antibacterial Antifungal Antiviral Cell-penetrating Peptides Hemolysis Toxicity standard
5 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB25122
poly-arginine (R5) R5
Antibacterial Antifungal Antiviral Cell-penetrating Peptides Hemolysis Toxicity
Anti-infective peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia CAFPdb dbAMP DRAVP 2.0 CellPPD CellPPD-MOD CPPsite3.0 PD_Hemolysis
standard
No
A 5-aa standard natural multi-activity (Antibacterial, Antifungal, Antiviral, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
RRRRR
Physicochemical Analysis
C30H62N20O6
ANDCEQGHILKMFPSTWYV
R
798.95
13.00
5
0
0
+5
4.05
-4.500
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
5
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
5
C30H62N20O6
798.95
13.00
+5
4.05
-4.500
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 8 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

A549

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Nucleic acid (pDNA)
Cytosol
Ineffective compared to the other polyarginines
In vitro
CCCCC
Evidence 2 Activity

Activity

Cell-penetrating Peptides

Target

Sw480 , Ht29 , Kdr And HUVEC Cells

Source & Reference

CPPsite3.0
CPPsite3

Other

Non-natural residues Linear L Cationic
Synthetic
Aurein 1,2 (Aur) and Aurein 1,2_mutant (Aurm)
R5-Aur and R5-Aurm groups of SW480 cultures presented more cytotoxic effects than the 5FU group. suggesting enhanced internalization of the Aur.
In vitro
Evidence 3 Activity

Activity

50% Cell death
Toxicity
>150 µg/mL
Cytotoxic
50% Cell death | >150 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 4 Activity

Activity

50% Cell death
Toxicity
>150 µg/mL
Cytotoxic
50% Cell death | >150 | µg/mL | target cell: Human Colon Epithelial Cells HCEC

Target

Human Colon Epithelial Cells HCEC

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 5 Activity

Activity

50% Cell death
Toxicity
>32 µg/mL
Cytotoxic
50% Cell death | >32 | µg/mL | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 6 Activity

Activity

50% Hemolysis
Toxicity
>32 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >32 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Design, Synthesis, and Nanostructure-Dependent Antibacterial Activity of Cationic Peptide Amphiphiles. | ACS Appl Mater Interfaces | 2019
Evidence 7 Activity

Activity

Toxicity
Hemolytic Cytotoxic
Hemolytic_activity: Not available | Cytotoxicity: Not available

Target

erythrocytes

Source & Reference

NA
DRAMP
Mol Pharm. 2013 May 6 10(5):1940-8.
Evidence 8 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis
Additional Detail Fields 1 fields
CCCCC