Back to search

Peptide record

TPDB25119

L-R4 Antibacterial Anticancer Antifungal Antiviral Cell-penetrating Peptides Toxicity standard
4 amino acids
Basic Information
3D PDB MODEL
Drag to rotate. Click a residue or atom to inspect it; the selected residue is highlighted in amber.
TPDB25119
L-R4
Antibacterial Anticancer Antifungal Antiviral Cell-penetrating Peptides Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides Delivery and barrier-penetrating peptides
Peptipedia CAFPdb dbAMP CellPPD CPPsite3.0
standard
No
A 4-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
RRRR
Physicochemical Analysis
C24H50N16O5
ANDCEQGHILKMFPSTWYV
R
642.77
12.88
4
0
0
+4
3.24
-4.500
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
4
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
0
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 4 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 0 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C24H50N16O5
642.77
12.88
+4
3.24
-4.500
Free
L
Cationic
Linear
Free
N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)N[C@@H](CCCN=C)C(=O)O
Evidence Records 4 records
Evidence 1 Activity

Activity

Cell-penetrating Peptides

Target

Caco-2 Cells

Assay & Model

Male Ddy mice weighing 30-40 g Ex-vivo ileum closed loop of Sprague Dawley rats weighing 180–220 g
Male Ddy mice weighing 30-40 g Ex-vivo ileum closed loop of Sprague Dawley rats weighing 180–220 g

Source & Reference

CPPsite3.0
CPPsite3

Other

Source Activity Label Source Definition
Cell-penetrating Peptides
CPPsite3.0 experimentally validated cell-penetrating peptide annotation.
Natural residues Linear L Cationic
Synthetic
Insulin
In vitro and in vivo
CCCCCCCC
Evidence 2 Activity

Activity

65% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
65% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short arginine-rich lipopeptides: From self-assembly to antimicrobial activity. | Biochim Biophys Acta | 2018
Evidence 3 Activity

Activity

<5% Hemolysis
Toxicity
100 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 100 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short arginine-rich lipopeptides: From self-assembly to antimicrobial activity. | Biochim Biophys Acta | 2018
Evidence 4 Activity

Activity

0% Hemolysis
Toxicity
500 µg/mL
Hemolytic Cytotoxic
0% Hemolysis | 500 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Short arginine-rich lipopeptides: From self-assembly to antimicrobial activity. | Biochim Biophys Acta | 2018
Additional Detail Fields 1 fields
CCCCCCCC