TPDB

3D PDB MODEL

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TPDB ID TPDB25108

Activity

Antibacterial Toxicity

Activity_category_statistics

Anti-infective peptides Toxicity and safety peptides

Database_Source

Peptipedia

Sequence_Type

standard

Has_Modification No

Description A 17-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.

Sequence

RRAIFASIRGYLGLRKR

FASTA

>TPDB25108|Antibacterial;Toxicity|length=17
RRAIFASIRGYLGLRKR

Formula C91H157N33O20

Absent Amino Acids NDCEQHMPTWV

Common Amino Acids R

Mass 2033.46

PI 12.58

Basic Residues 6

Acidic Residues 0

Hydrophobic Residues 8

Net Charge +6

Boman Index 1.04

Hydrophobicity -0.371

Aliphatic Index 103.53

Half Life

Mammalian: 1 hour Yeast: 2 min E.coli: 2 min

Extinction Coefficient Cystines 1490

Absorbance 280nm 73.27

Polar Residues 2

number

2

A

5

R

0

N

0

D

0

C

0

E

0

Q

2

G

0

H

2

I

2

L

1

K

0

M

1

F

0

P

1

S

0

T

0

W

1

Y

0

V

Amino Acid Distribution

A: 2 R: 5 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 2 H: 0 I: 2 L: 2 K: 1 M: 0 F: 1 P: 0 S: 1 T: 0 W: 0 Y: 1 V: 0

Length

17

Formula

C91H157N33O20

Mass

2033.46

PI

12.58

Net Charge

+6

Boman Index

1.04

Hydrophobicity

-0.371

Evidence 1 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 4 µg/mL

Target

Target Organism Escherichia coli ATCC 25922

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 4 ug/ml), S. enteritidis (MIC 8-16 ug/ml), and S.aureus ATCC 29213 (MIC 128 ug/ml).

Evidence 2 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 8-16 µg/mL

Target

Target Organism S. enteritidis

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 4 ug/ml), S. enteritidis (MIC 8-16 ug/ml), and S.aureus ATCC 29213 (MIC 128 ug/ml).

Evidence 3 Activity

Activity

Activity Endpoint MIC

Detail Source Activity Antibacterial

Activity Measurement 128 µg/mL

Target

Target Organism S.aureus ATCC 29213

Source & Reference

Database Source NA

Other

Evidence Text

Active against E. coli ATCC 25922 (MIC 4 ug/ml), S. enteritidis (MIC 8-16 ug/ml), and S.aureus ATCC 29213 (MIC 128 ug/ml).

Evidence 4 Activity

Activity

Activity Endpoint 50% Hemolysis

Detail Source Activity Toxicity

Activity Measurement >128 µg/mL

Toxicity Type Hemolytic Cytotoxic

Toxicity Raw

50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Target Cell Pig erythrocytes

Source & Reference

Database Source NA

Source Database DBAASP

Reference

Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022