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Peptide record

TPDB25107

Antibacterial Anticancer Antifungal Toxicity standard
31 amino acids
Basic Information
3D PDB MODEL
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TPDB25107
Antibacterial Anticancer Antifungal Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia AFP-GFuse
standard
No
A 31-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia and AFP-GFuse, with an available 3D structural model.
Sequence
RRAAHGLLPRLRAPPPFHKRCVCLCRTAPPP
Physicochemical Analysis
C154H256N54O33S3
NDEQIMSWY
P
3488.25
12.11
9
0
10
+7
6.37
-0.410
72.58
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
125
3.58
4
Residue Composition
number
4
A
6
R
0
N
0
D
3
C
0
E
0
Q
1
G
2
H
0
I
4
L
1
K
0
M
1
F
7
P
0
S
1
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 4 R: 6 N: 0 D: 0 C: 3 E: 0 Q: 0 G: 1 H: 2 I: 0 L: 4 K: 1 M: 0 F: 1 P: 7 S: 0 T: 1 W: 0 Y: 0 V: 1
Chemical Descriptors
31
C154H256N54O33S3
3488.25
12.11
+7
6.37
-0.410
Evidence Records 18 records
Evidence 1 Activity

Activity

MIC
Antibacterial
1.5-3 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

active against Gram+ S. aureus (MIC 1.5-3 uM), L. monocytogenes (MIC 1.5-3 uM), E. faecalis (MIC 1.5-3 uM), E. faecium (MIC 1.5 uM), S.
Evidence 2 Activity

Activity

MIC
Antibacterial
1.5-3 µM

Target

L. monocytogenes

Source & Reference

NA

Other

active against Gram+ S. aureus (MIC 1.5-3 uM), L. monocytogenes (MIC 1.5-3 uM), E. faecalis (MIC 1.5-3 uM), E. faecium (MIC 1.5 uM), S. epidermidis (MIC 3-6 uM), Gram-
Evidence 3 Activity

Activity

MIC
Antibacterial
1.5-3 µM

Target

Enterococcus faecalis

Source & Reference

NA

Other

active against Gram+ S. aureus (MIC 1.5-3 uM), L. monocytogenes (MIC 1.5-3 uM), E. faecalis (MIC 1.5-3 uM), E. faecium (MIC 1.5 uM), S. epidermidis (MIC 3-6 uM), Gram- P. aeruginosa (MIC 1.5-3 uM)
Evidence 4 Activity

Activity

MIC
Antibacterial
1.5 µM

Target

E. faecium

Source & Reference

NA

Other

m+ S. aureus (MIC 1.5-3 uM), L. monocytogenes (MIC 1.5-3 uM), E. faecalis (MIC 1.5-3 uM), E. faecium (MIC 1.5 uM), S. epidermidis (MIC 3-6 uM), Gram- P. aeruginosa (MIC 1.5-3 uM), E. coli (MIC 3-6 uM), A
Evidence 5 Activity

Activity

MIC
Antibacterial
3-6 µM

Target

Staphylococcus epidermidis

Source & Reference

NA

Other

M), L. monocytogenes (MIC 1.5-3 uM), E. faecalis (MIC 1.5-3 uM), E. faecium (MIC 1.5 uM), S. epidermidis (MIC 3-6 uM), Gram- P. aeruginosa (MIC 1.5-3 uM), E. coli (MIC 3-6 uM), A. baunmannii (MIC 3-6 uM), fu
Evidence 6 Activity

Activity

MIC
Antibacterial
1.5-3 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

, E. faecalis (MIC 1.5-3 uM), E. faecium (MIC 1.5 uM), S. epidermidis (MIC 3-6 uM), Gram- P. aeruginosa (MIC 1.5-3 uM), E. coli (MIC 3-6 uM), A. baunmannii (MIC 3-6 uM), fungi C. neoformans (MFC 6-12 uM), F.
Evidence 7 Activity

Activity

MIC
Antibacterial
3-6 µM

Target

Escherichia coli

Source & Reference

NA

Other

E. faecium (MIC 1.5 uM), S. epidermidis (MIC 3-6 uM), Gram- P. aeruginosa (MIC 1.5-3 uM), E. coli (MIC 3-6 uM), A. baunmannii (MIC 3-6 uM), fungi C. neoformans (MFC 6-12 uM), F. graminearum (MFC 1.5-3
Evidence 8 Activity

Activity

MIC
Antibacterial
3-6 µM

Target

A. baunmannii

Source & Reference

NA

Other

), S. epidermidis (MIC 3-6 uM), Gram- P. aeruginosa (MIC 1.5-3 uM), E. coli (MIC 3-6 uM), A. baunmannii (MIC 3-6 uM), fungi C. neoformans (MFC 6-12 uM), F. graminearum (MFC 1.5-3 uM), F. solani (MFC 1.5-3 u
Evidence 9 Activity

Activity

MIC
Antifungal
1.5-3 µM

Target

Staphylococcus aureus

Source & Reference

NA

Other

active against Gram+ S. aureus (MIC 1.5-3 uM), L. monocytogenes (MIC 1.5-3 uM), E. faecalis (MIC 1.5-3 uM), E. faecium (MIC 1.5 uM), S.
Evidence 10 Activity

Activity

MIC
Antifungal
1.5-3 µM

Target

L. monocytogenes

Source & Reference

NA

Other

active against Gram+ S. aureus (MIC 1.5-3 uM), L. monocytogenes (MIC 1.5-3 uM), E. faecalis (MIC 1.5-3 uM), E. faecium (MIC 1.5 uM), S. epidermidis (MIC 3-6 uM), Gram-
Evidence 11 Activity

Activity

MIC
Antifungal
1.5-3 µM

Target

Enterococcus faecalis

Source & Reference

NA

Other

active against Gram+ S. aureus (MIC 1.5-3 uM), L. monocytogenes (MIC 1.5-3 uM), E. faecalis (MIC 1.5-3 uM), E. faecium (MIC 1.5 uM), S. epidermidis (MIC 3-6 uM), Gram- P. aeruginosa (MIC 1.5-3 uM)
Evidence 12 Activity

Activity

MIC
Antifungal
1.5 µM

Target

E. faecium

Source & Reference

NA

Other

m+ S. aureus (MIC 1.5-3 uM), L. monocytogenes (MIC 1.5-3 uM), E. faecalis (MIC 1.5-3 uM), E. faecium (MIC 1.5 uM), S. epidermidis (MIC 3-6 uM), Gram- P. aeruginosa (MIC 1.5-3 uM), E. coli (MIC 3-6 uM), A
Evidence 13 Activity

Activity

MIC
Antifungal
3-6 µM

Target

Staphylococcus epidermidis

Source & Reference

NA

Other

M), L. monocytogenes (MIC 1.5-3 uM), E. faecalis (MIC 1.5-3 uM), E. faecium (MIC 1.5 uM), S. epidermidis (MIC 3-6 uM), Gram- P. aeruginosa (MIC 1.5-3 uM), E. coli (MIC 3-6 uM), A. baunmannii (MIC 3-6 uM), fu
Evidence 14 Activity

Activity

MIC
Antifungal
1.5-3 µM

Target

Pseudomonas aeruginosa

Source & Reference

NA

Other

, E. faecalis (MIC 1.5-3 uM), E. faecium (MIC 1.5 uM), S. epidermidis (MIC 3-6 uM), Gram- P. aeruginosa (MIC 1.5-3 uM), E. coli (MIC 3-6 uM), A. baunmannii (MIC 3-6 uM), fungi C. neoformans (MFC 6-12 uM), F.
Evidence 15 Activity

Activity

MIC
Antifungal
3-6 µM

Target

Escherichia coli

Source & Reference

NA

Other

E. faecium (MIC 1.5 uM), S. epidermidis (MIC 3-6 uM), Gram- P. aeruginosa (MIC 1.5-3 uM), E. coli (MIC 3-6 uM), A. baunmannii (MIC 3-6 uM), fungi C. neoformans (MFC 6-12 uM), F. graminearum (MFC 1.5-3
Evidence 16 Activity

Activity

MIC
Antifungal
3-6 µM

Target

A. baunmannii

Source & Reference

NA

Other

), S. epidermidis (MIC 3-6 uM), Gram- P. aeruginosa (MIC 1.5-3 uM), E. coli (MIC 3-6 uM), A. baunmannii (MIC 3-6 uM), fungi C. neoformans (MFC 6-12 uM), F. graminearum (MFC 1.5-3 uM), F. solani (MFC 1.5-3 u
Evidence 17 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human embryonic kidney HEK293T cells

Target

Human embryonic kidney HEK293T cells

Source & Reference

NA
DBAASP
A Novel Antimicrobial Peptide Spampcin56-86 from Scylla paramamosain Exerting Rapid Bactericidal and Anti-Biofilm Activity In Vitro and Anti-Infection In Vivo. | Int J Mol Sci | 2022
Evidence 18 Activity

Activity

<5% Hemolysis
Toxicity
250 µg/mL
Hemolytic Cytotoxic
<5% Hemolysis | 250 | µg/mL | target cell: Mouse erythrocytes

Target

Mouse erythrocytes

Source & Reference

NA
DBAASP
A Novel Antimicrobial Peptide Spampcin56-86 from Scylla paramamosain Exerting Rapid Bactericidal and Anti-Biofilm Activity In Vitro and Anti-Infection In Vivo. | Int J Mol Sci | 2022