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Peptide record

TPDB25097

Antibacterial Anticancer Antifungal Antiviral Hemolysis Toxicity standard
4 amino acids
Basic Information
3D PDB MODEL
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TPDB25097
Antibacterial Anticancer Antifungal Antiviral Hemolysis Toxicity
Anti-infective peptides Cancer-related peptides Toxicity and safety peptides
Peptipedia CAFPdb dbAMP PD_Hemolysis
standard
No
A 4-aa standard natural multi-activity (Antibacterial, Anticancer, Antifungal, and other sources) peptide sequence curated from Peptipedia, CAFPdb, dbAMP, and other sources, with an available 3D structural model.
Sequence
RRKK
Physicochemical Analysis
C24H50N12O5
ANDCEQGHILMFPSTWYV
RK
586.74
12.42
4
0
0
+4
3.60
-4.200
0.00
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
0
Residue Composition
number
0
A
2
R
0
N
0
D
0
C
0
E
0
Q
0
G
0
H
0
I
0
L
2
K
0
M
0
F
0
P
0
S
0
T
0
W
0
Y
0
V
Amino Acid Distribution
A: 0 R: 2 N: 0 D: 0 C: 0 E: 0 Q: 0 G: 0 H: 0 I: 0 L: 0 K: 2 M: 0 F: 0 P: 0 S: 0 T: 0 W: 0 Y: 0 V: 0
Chemical Descriptors
4
C24H50N12O5
586.74
12.42
+4
3.60
-4.200
Evidence Records 3 records
Evidence 1 Activity

Activity

50% Hemolysis
Toxicity
65.4±1.5 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | 65.4±1.5 | µg/mL | target cell: Human erythrocytes

Target

Human erythrocytes

Source & Reference

NA
DBAASP
Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity. | Int J Mol Sci | 2020
Evidence 2 Activity

Activity

IC50
Toxicity
8.1±1.1 µg/mL
Cytotoxic
IC50 | 8.1±1.1 | µg/mL | target cell: Human keratinocytes HaCat

Target

Human keratinocytes HaCat

Source & Reference

NA
DBAASP
Effect of Disulfide Cyclization of Ultrashort Cationic Lipopeptides on Antimicrobial Activity and Cytotoxicity. | Int J Mol Sci | 2020
Evidence 3 Hemolysis

Source & Reference

PD_Hemolysis
PD_Hemolysis