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Peptide record

TPDB25048

Antibacterial Toxicity standard
18 amino acids
Basic Information
3D PDB MODEL
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TPDB25048
Antibacterial Toxicity
Anti-infective peptides Toxicity and safety peptides
Peptipedia
standard
No
A 18-aa standard natural multi-activity (Antibacterial and Toxicity) peptide sequence curated from Peptipedia, with an available 3D structural model.
Sequence
RPRPQQVPPRPPHPRLRR
Physicochemical Analysis
C98H166N40O21
ANDCEGIKMFSTWY
P
2240.65
13.10
7
0
2
+6
9.64
-2.244
37.78
Mammalian: 1 hour Yeast: 2 min E.coli: 2 min
0
0.00
2
Residue Composition
number
0
A
6
R
0
N
0
D
0
C
0
E
2
Q
0
G
1
H
0
I
1
L
0
K
0
M
0
F
7
P
0
S
0
T
0
W
0
Y
1
V
Amino Acid Distribution
A: 0 R: 6 N: 0 D: 0 C: 0 E: 0 Q: 2 G: 0 H: 1 I: 0 L: 1 K: 0 M: 0 F: 0 P: 7 S: 0 T: 0 W: 0 Y: 0 V: 1
Chemical Descriptors
18
C98H166N40O21
2240.65
13.10
+6
9.64
-2.244
Evidence Records 5 records
Evidence 1 Activity

Activity

MIC
Antibacterial
2-4 µg/mL

Target

Escherichia coli ATCC 25922

Source & Reference

NA

Other

Active against E. coli ATCC 25922 (MIC 2-4 ug/ml), S. enteritidis (MIC 4-8 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).
Evidence 2 Activity

Activity

MIC
Antibacterial
4-8 µg/mL

Target

S. enteritidis

Source & Reference

NA

Other

Active against E. coli ATCC 25922 (MIC 2-4 ug/ml), S. enteritidis (MIC 4-8 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).
Evidence 3 Activity

Activity

MIC
Antibacterial
>128 µg/mL

Target

S.aureus ATCC 29213

Source & Reference

NA

Other

Active against E. coli ATCC 25922 (MIC 2-4 ug/ml), S. enteritidis (MIC 4-8 ug/ml), and S.aureus ATCC 29213 (MIC >128 ug/ml).
Evidence 4 Activity

Activity

50% Hemolysis
Toxicity
>128 µg/mL
Hemolytic Cytotoxic
50% Hemolysis | >128 | µg/mL | target cell: Pig erythrocytes

Target

Pig erythrocytes

Source & Reference

NA
DBAASP
Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022
Evidence 5 Activity

Activity

Toxicity
Cytotoxic
NA | target cell: Human embryonic kidney HEK293 cells

Target

Human embryonic kidney HEK293 cells

Source & Reference

NA
DBAASP
Associating Biological Activity and Predicted Structure of Antimicrobial Peptides from Amphibians and Insects | Antibiotics (Basel) | 2022